716 Phase 2 study of the HER2-targeting TLR7/8 immune stimulating antibody conjugate (ISAC) BDC-1001 monotherapy +/- nivolumab in patients with HER2+ colorectal, endometrial, or gastroesophageal cancer

• Jean-Yves Blay,
• Antoine Italiano,
• Stephane Champiat,
• Paolo Antonio Ascierto,
• Manish Sharma,
• Jeeyun Lee,
• Luis Paz-Ares Rodriguez,
• Keun-Wook Lee,
• Yoon-Koo Kang,
• Drew Rasco,
• Edith A Perez,
• Mariano Ponz-Sarvise,
• Lu Xu,
• Jean-Philippe Spano,
• Coya Tapia,
• Ecaterina Dumbrava,
• Kathleen Moore,
• Jason Ptacek,
• Michele Magni,
• Alfonso Cortes Salgado,
• Ming Yin,
• Agnese Losurdo,
• Antoine Deleuze,
• Mark D Pegram,
• Ardaman Shergill,
• Alexander I Spira,
• Michael N Alonso,
• Joan Albanell Mestres,
• Marta GilMartin,
• Arielle Heeke,
• Ana Oaknin Benzaquen,
• Ignacio Ortego Zabalza,
• Haeseong Park,
• Cecile Vicier,
• Ivan Victoria,
• Benjamin Weinberg,
• Bob T Li

Affiliations

Jean-Yves Blay

Medical Oncology, Centre Léon Bérard, Lyon, Rhône-Alpes, France

Antoine Italiano

3Institut Bergonié, Bordeaux, France

Stephane Champiat

2Gustave Roussy Comprehensive Cancer Center, Villejuif, France

Paolo Antonio Ascierto

3 Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, IRCCS Fondazione G. Pascale, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy

Manish Sharma

3START Midwest, Grand Rapids, MI, USA

Jeeyun Lee

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Luis Paz-Ares Rodriguez

Aff460 Gabinete Radiologico del Dr. Pita, NA Madrid Spain

Keun-Wook Lee

Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, South Korea

Yoon-Koo Kang

10 Asan Medical Center, Seoul, South Korea

Drew Rasco

2The START Center for Cancer Care, San Antonio, TX, USA

Edith A Perez

Aff2 grid.477659.eNorth Central Cancer Treatment Group Rochester MN USA

Mariano Ponz-Sarvise

Aff1 0000 0001 2191 685Xgrid.411730.0Clinica Universidad de Navarra Avenida Pio XII, 36 31008 Pamplona Spain

Lu Xu

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China

Jean-Philippe Spano

4Groupe Hospitalier Pitié-Salpêtrière, Paris, France

Coya Tapia

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Ecaterina Dumbrava

1MD Anderson Cancer Center, Houston, TX, USA

Kathleen Moore

University of Oklahoma Health Sciences Center, Oklahoma, OK, USA

Jason Ptacek

1Ionpath, Inc, Menlo Park, USA

Michele Magni

Immunotherapy and Innovative Therapeutics Unit, Medical Oncology and Hematology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Alfonso Cortes Salgado

4Hospital Universitario Ramón

Ming Yin

1 Department of Psychology, Global and Community Mental Health Research Group, The University of Macau, Macao (SAR), China

Agnese Losurdo

IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy

Antoine Deleuze

1 Department of Medical Oncology, Centre Eugène Marquis, Rennes, France

Mark D Pegram

Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA

Ardaman Shergill

University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA

Alexander I Spira

2Next Oncology, Fairfax, VA, USA

Michael N Alonso

1Bolt Biotherapeutics, Redwood City, CA, USA

Joan Albanell Mestres

2Hospital del Mar, Barcelona, Spain, Spain

Marta GilMartin

8Institut Català d’Oncologia, L’Hospitalet, Barcelona, Spain

Arielle Heeke

9Levine Cancer Institute, Charlotte, NC, USA

Ana Oaknin Benzaquen

17Vall d’Hebron University Hospital, Vall d’Hebron, Institute of Oncology (VHIO), Barcelona, Spain

Ignacio Ortego Zabalza

18MD Anderson Cancer Center, Madrid, Spain

Haeseong Park

19Dana-Farber Cancer Institute, Boston, MA, USA

Cecile Vicier

28Institut Paoli-Calmette, Marseille, France

Ivan Victoria

29Hospital Clinic de Barcelona, Barcelona, Spain

Benjamin Weinberg

30Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA

Bob T Li

33Memorial Sloan Kettering Cancer Center, New York, NY, USA