Nature Communications (Mar 2021)
SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
- Jun Wu,
- Boyun Liang,
- Cunrong Chen,
- Hua Wang,
- Yaohui Fang,
- Shu Shen,
- Xiaoli Yang,
- Baoju Wang,
- Liangkai Chen,
- Qi Chen,
- Yang Wu,
- Jia Liu,
- Xuecheng Yang,
- Wei Li,
- Bin Zhu,
- Wenqing Zhou,
- Huan Wang,
- Sumeng Li,
- Sihong Lu,
- Di Liu,
- Huadong Li,
- Adalbert Krawczyk,
- Mengji Lu,
- Dongliang Yang,
- Fei Deng,
- Ulf Dittmer,
- Mirko Trilling,
- Xin Zheng
Affiliations
- Jun Wu
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Boyun Liang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Cunrong Chen
- Department of ICU, Fujian Medical University Union Hospital
- Hua Wang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Yaohui Fang
- State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences
- Shu Shen
- State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences
- Xiaoli Yang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Baoju Wang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Liangkai Chen
- Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
- Qi Chen
- Hubei Provincial Center for Disease Control and Prevention
- Yang Wu
- Hubei Provincial Center for Disease Control and Prevention
- Jia Liu
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xuecheng Yang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Wei Li
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Bin Zhu
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Wenqing Zhou
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Huan Wang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Sumeng Li
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Sihong Lu
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Di Liu
- Pritzker School of Medicine, University of Chicago
- Huadong Li
- Jin Yin-tan Hospital
- Adalbert Krawczyk
- Department of Infectious Diseases, University Hospital of Essen, University of Duisburg-Essen
- Mengji Lu
- Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology
- Dongliang Yang
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Fei Deng
- State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences
- Ulf Dittmer
- Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology
- Mirko Trilling
- Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology
- Xin Zheng
- Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-021-22034-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
A better understanding of longitudinal changes in antibody responses in COVID-19 patients is needed. Here the authors analyze anti-spike and anti-nucleocapsid antibody responses to Sars-CoV-2 over a course of 6 months in a large cohort of patients with COVID-19, showing that IgM is mostly not detectable after 3 months, whereas IgG responses contract, yet remain at high levels at 6 months.
