Granular Cell Tumour: A Clinicopathological Study with Review of Literature

Abstract

Introduction: Granular Cell Tumours (GCTs) can occur in any part of the body. Many a times, they occur as a small swelling, clinically suspected to be a benign process. Histologically, they are characterised by the presence of cells with abundant granular cytoplasm. Aims: To study the clinicopathological spectrum of GCTs diagnosed. Materials and Methods: Data were collected from the archives of the Department of Pathology, on diagnosed cases of GCTs for a period of five years; from 2012 to 2017 and a total of 22 cases were included in the study. The slides, including special stains and Immunohistochemistry (IHC), whenever performed, were retrieved and studied. The results were tabulated and analysed. Results: In the present study 22 cases of GCT were described, commonly involving skin and subcutaneous tissue. Most of the lesions were less than a centimeter in size. Females were more often affected. On follow-up, no recurrence was noted. Conclusion: Granular cell tumours should be a part of the diagnostic differentials whenever lesions having cells with granular cytoplasm are encountered.

Keywords

• benign
• diagnosis
• malignant
• spectrum