Nature Communications (Apr 2017)
Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis
- Sonja Reißig,
- Yilang Tang,
- Alexei Nikolaev,
- Katharina Gerlach,
- Christine Wolf,
- Kathrin Davari,
- Christian Gallus,
- Joumana Masri,
- Ilgiz A. Mufazalov,
- Markus F. Neurath,
- F. Thomas Wunderlich,
- Jörn M. Schattenberg,
- Peter R. Galle,
- Benno Weigmann,
- Ari Waisman,
- Elke Glasmacher,
- Nadine Hövelmeyer
Affiliations
- Sonja Reißig
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Yilang Tang
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Alexei Nikolaev
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Katharina Gerlach
- Department of Medicine I, University Erlangen-Nürnberg
- Christine Wolf
- Helmholtz Zentrum München, Institute of Diabetes and Obesity (IDO), German Center for Diabetes Research (DZD)
- Kathrin Davari
- Helmholtz Zentrum München, Institute of Diabetes and Obesity (IDO), German Center for Diabetes Research (DZD)
- Christian Gallus
- Helmholtz Zentrum München, Institute of Diabetes and Obesity (IDO), German Center for Diabetes Research (DZD)
- Joumana Masri
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Ilgiz A. Mufazalov
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Markus F. Neurath
- Department of Medicine I, University Erlangen-Nürnberg
- F. Thomas Wunderlich
- Max Planck Institute for Metabolism Research, CECAD, CMMC, Institute for Genetics
- Jörn M. Schattenberg
- Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg, University of Mainz
- Peter R. Galle
- Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg, University of Mainz
- Benno Weigmann
- Department of Medicine I, University Erlangen-Nürnberg
- Ari Waisman
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- Elke Glasmacher
- Helmholtz Zentrum München, Institute of Diabetes and Obesity (IDO), German Center for Diabetes Research (DZD)
- Nadine Hövelmeyer
- Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg, University of Mainz
- DOI
- https://doi.org/10.1038/ncomms15069
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.
