Nature Communications (May 2021)
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
- Ren-Bo Ding,
- Ping Chen,
- Barani Kumar Rajendran,
- Xueying Lyu,
- Haitao Wang,
- Jiaolin Bao,
- Jianming Zeng,
- Wenhui Hao,
- Heng Sun,
- Ada Hang-Heng Wong,
- Monica Vishnu Valecha,
- Eun Ju Yang,
- Sek Man Su,
- Tak Kan Choi,
- Shuiming Liu,
- Kin Iong Chan,
- Ling-Lin Yang,
- Jingbo Wu,
- Kai Miao,
- Qiang Chen,
- Joong Sup Shim,
- Xiaoling Xu,
- Chu-Xia Deng
Affiliations
- Ren-Bo Ding
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Ping Chen
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Barani Kumar Rajendran
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xueying Lyu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Haitao Wang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jiaolin Bao
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jianming Zeng
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Wenhui Hao
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Heng Sun
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Ada Hang-Heng Wong
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Monica Vishnu Valecha
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Eun Ju Yang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Sek Man Su
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Tak Kan Choi
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Shuiming Liu
- Kiang Wu Hospital
- Kin Iong Chan
- Kiang Wu Hospital
- Ling-Lin Yang
- Department of Oncology, The Affiliated Hospital of Southwest Medical University
- Jingbo Wu
- Department of Oncology, The Affiliated Hospital of Southwest Medical University
- Kai Miao
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Qiang Chen
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Joong Sup Shim
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaoling Xu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Chu-Xia Deng
- Cancer Centre, Faculty of Health Sciences, University of Macau
- DOI
- https://doi.org/10.1038/s41467-021-23379-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.
