Nature Communications (Jun 2021)
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
- Henry Nording,
- Lasse Baron,
- David Haberthür,
- Frederic Emschermann,
- Matthias Mezger,
- Manuela Sauter,
- Reinhard Sauter,
- Johannes Patzelt,
- Kai Knoepp,
- Anne Nording,
- Moritz Meusel,
- Roza Meyer-Saraei,
- Ruslan Hlushchuk,
- Daniel Sedding,
- Oliver Borst,
- Ingo Eitel,
- Christian M. Karsten,
- Robert Feil,
- Bernd Pichler,
- Jeanette Erdmann,
- Admar Verschoor,
- Emmanouil Chavakis,
- Triantafyllos Chavakis,
- Philipp von Hundelshausen,
- Jörg Köhl,
- Meinrad Gawaz,
- Harald F. Langer
Affiliations
- Henry Nording
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- Lasse Baron
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- David Haberthür
- Institute of Anatomy, University of Bern
- Frederic Emschermann
- University Hospital, Department of Cardiovascular Medicine, Eberhard Karls University
- Matthias Mezger
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- Manuela Sauter
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- Reinhard Sauter
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- Johannes Patzelt
- University Hospital, Medical Clinic II, University Heart Center Lübeck
- Kai Knoepp
- Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Martin-Luther-University Halle (Saale)
- Anne Nording
- Institute of Medical Genetics and Applied Genomics, Eberhard Karls University
- Moritz Meusel
- University Hospital, Medical Clinic II, University Heart Center Lübeck
- Roza Meyer-Saraei
- DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel
- Ruslan Hlushchuk
- Institute of Anatomy, University of Bern
- Daniel Sedding
- Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Martin-Luther-University Halle (Saale)
- Oliver Borst
- University Hospital, Department of Cardiovascular Medicine, Eberhard Karls University
- Ingo Eitel
- DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel
- Christian M. Karsten
- Institute for Systemic Inflammation Research, University of Lübeck
- Robert Feil
- Interfaculty Institute of Biochemistry, University of Tübingen
- Bernd Pichler
- Institute for Preclinical Imaging, Eberhard Karls University
- Jeanette Erdmann
- DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel
- Admar Verschoor
- Institute for Systemic Inflammation Research, University of Lübeck
- Emmanouil Chavakis
- Department for Internal Medicine III/Cardiology, University Hospital of the Johann-Wolfgang Goethe University
- Triantafyllos Chavakis
- Department of Clinical Pathobiochemistry, Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden
- Philipp von Hundelshausen
- Institute for Cardiovascular Prevention, Ludwig Maximilians University Munich
- Jörg Köhl
- Institute for Systemic Inflammation Research, University of Lübeck
- Meinrad Gawaz
- University Hospital, Department of Cardiovascular Medicine, Eberhard Karls University
- Harald F. Langer
- Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck
- DOI
- https://doi.org/10.1038/s41467-021-23499-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
As more intersection points between platelets and the immune system are found, the role of platelets for vessel growth in the adult organism remains unclear. The authors demonstrate that platelets negatively modulate revascularization through CXCL4 secretion induced by activation C5aR1 on their surface.
