Frontiers in Physics (Oct 2020)
Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project
- Nicholas T. Henthorn,
- Nicholas T. Henthorn,
- Olga Sokol,
- Marco Durante,
- Marco Durante,
- Ludovic De Marzi,
- Frederic Pouzoulet,
- Justyna Miszczyk,
- Pawel Olko,
- Sytze Brandenburg,
- Sytze Brandenburg,
- Marc Jan van Goethem,
- Marc Jan van Goethem,
- Lara Barazzuol,
- Lara Barazzuol,
- Makbule Tambas,
- Johannes A. Langendijk,
- Marie Davídková,
- Vladimír Vondráĉek,
- Elisabeth Bodenstein,
- Joerg Pawelke,
- Joerg Pawelke,
- Antony J. Lomax,
- Antony J. Lomax,
- Damien C. Weber,
- Damien C. Weber,
- Damien C. Weber,
- Alexandru Dasu,
- Alexandru Dasu,
- Bo Stenerlöw,
- Per R. Poulsen,
- Brita S. Sørensen,
- Cai Grau,
- Mateusz K. Sitarz,
- Anne-Catherine Heuskin,
- Stephane Lucas,
- John W. Warmenhoven,
- John W. Warmenhoven,
- Michael J. Merchant,
- Michael J. Merchant,
- Ran I. Mackay,
- Ran I. Mackay,
- Karen J. Kirkby,
- Karen J. Kirkby
Affiliations
- Nicholas T. Henthorn
- Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom
- Nicholas T. Henthorn
- Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom
- Olga Sokol
- Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany
- Marco Durante
- Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany
- Marco Durante
- Department of Condensed Matter Physics, Technische Universität Darmstadt, Darmstadt, Germany
- Ludovic De Marzi
- Radiation Oncology Department, Institut Curie, PSL Research University, Paris, France
- Frederic Pouzoulet
- Translational Research Department, Experimental Radiotherapy Platform, Institut Curie, PSL Research University, Orsay, France
- Justyna Miszczyk
- Department of Experimental Physics of Complex Systems, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland
- Pawel Olko
- Department of Experimental Physics of Complex Systems, Institute of Nuclear Physics Polish Academy of Sciences, Krakow, Poland
- Sytze Brandenburg
- KVI-Center for Advanced Radiation Technology, University of Groningen, Groningen, Netherlands
- Sytze Brandenburg
- Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Marc Jan van Goethem
- KVI-Center for Advanced Radiation Technology, University of Groningen, Groningen, Netherlands
- Marc Jan van Goethem
- Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Lara Barazzuol
- Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Lara Barazzuol
- 0Section of Molecular Cell Biology, Department of Biomedical Sciences of Cell and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Makbule Tambas
- Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Johannes A. Langendijk
- Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
- Marie Davídková
- 1Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Prague, Czechia
- Vladimír Vondráĉek
- 2Proton Therapy Center Czech, Prague, Czechia
- Elisabeth Bodenstein
- 3OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Helmholtz-Zentrum Dresden – Rossendorf, Technische Universität Dresden, Dresden, Germany
- Joerg Pawelke
- 3OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Helmholtz-Zentrum Dresden – Rossendorf, Technische Universität Dresden, Dresden, Germany
- Joerg Pawelke
- 4Helmholtz-Zentrum Dresden – Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany
- Antony J. Lomax
- 5Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland
- Antony J. Lomax
- 6Department of Physics, ETH, Zurich, Switzerland
- Damien C. Weber
- 5Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland
- Damien C. Weber
- 7Department of Radiation Oncology, University of Zurich, Zurich, Switzerland
- Damien C. Weber
- 8Department of Radiation Oncology, University of Bern, Bern, Switzerland
- Alexandru Dasu
- 9The Skandion Clinic, Uppsala, Sweden
- Alexandru Dasu
- 0Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
- Bo Stenerlöw
- 0Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
- Per R. Poulsen
- 1Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
- Brita S. Sørensen
- 1Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
- Cai Grau
- 1Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
- Mateusz K. Sitarz
- 1Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
- Anne-Catherine Heuskin
- 2LARN-Laboratory, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium
- Stephane Lucas
- 2LARN-Laboratory, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium
- John W. Warmenhoven
- Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom
- John W. Warmenhoven
- Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom
- Michael J. Merchant
- Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom
- Michael J. Merchant
- Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom
- Ran I. Mackay
- Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom
- Ran I. Mackay
- 3Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom
- Karen J. Kirkby
- Division of Cancer Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, The University of Manchester, Manchester, United Kingdom
- Karen J. Kirkby
- Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, United Kingdom
- DOI
- https://doi.org/10.3389/fphy.2020.565055
- Journal volume & issue
-
Vol. 8
Abstract
Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biological mechanisms in general, necessitate experimental investigation. The “Infrastructure in Proton International Research” (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on the topic of proton and ion therapy across Europe, and to facilitate the sharing of information and resources. This work highlights the radiobiological capabilities of the INSPIRE partners, providing details of physics (available particle types and energies), biology (sample preparation and post-irradiation analysis), and researcher access (the process of applying for beam time). The collection of information reported here is designed to provide researchers both in Europe and worldwide with the tools required to select the optimal center for their research needs. We also highlight areas of redundancy in capabilities and suggest areas for future investment.
Keywords
