Experimental validation of a bias in apparent exchange rate measurement

Abstract

Double diffusion encoding (DDE) MRI is a technique in which two diffusion weighted periods are applied between excitation and acquisition. This allows to acquire structural information (as pore size and shape) and molecular exchange between compartments, in terms of apparent exchange rate (AXR). However, it has not been well investigated yet whether the diffusion restriction underlying DDE size estimation may compromise AXR results.

Keywords

• double diffusion encoding (dde)
• apparent exchange rate
• water-in-oil emulsion