Cell Genomics (Nov 2021)
GA4GH: International policies and standards for data sharing across genomic research and healthcare
- Heidi L. Rehm,
- Angela J.H. Page,
- Lindsay Smith,
- Jeremy B. Adams,
- Gil Alterovitz,
- Lawrence J. Babb,
- Maxmillian P. Barkley,
- Michael Baudis,
- Michael J.S. Beauvais,
- Tim Beck,
- Jacques S. Beckmann,
- Sergi Beltran,
- David Bernick,
- Alexander Bernier,
- James K. Bonfield,
- Tiffany F. Boughtwood,
- Guillaume Bourque,
- Sarion R. Bowers,
- Anthony J. Brookes,
- Michael Brudno,
- Matthew H. Brush,
- David Bujold,
- Tony Burdett,
- Orion J. Buske,
- Moran N. Cabili,
- Daniel L. Cameron,
- Robert J. Carroll,
- Esmeralda Casas-Silva,
- Debyani Chakravarty,
- Bimal P. Chaudhari,
- Shu Hui Chen,
- J. Michael Cherry,
- Justina Chung,
- Melissa Cline,
- Hayley L. Clissold,
- Robert M. Cook-Deegan,
- Mélanie Courtot,
- Fiona Cunningham,
- Miro Cupak,
- Robert M. Davies,
- Danielle Denisko,
- Megan J. Doerr,
- Lena I. Dolman,
- Edward S. Dove,
- L. Jonathan Dursi,
- Stephanie O.M. Dyke,
- James A. Eddy,
- Karen Eilbeck,
- Kyle P. Ellrott,
- Susan Fairley,
- Khalid A. Fakhro,
- Helen V. Firth,
- Michael S. Fitzsimons,
- Marc Fiume,
- Paul Flicek,
- Ian M. Fore,
- Mallory A. Freeberg,
- Robert R. Freimuth,
- Lauren A. Fromont,
- Jonathan Fuerth,
- Clara L. Gaff,
- Weiniu Gan,
- Elena M. Ghanaim,
- David Glazer,
- Robert C. Green,
- Malachi Griffith,
- Obi L. Griffith,
- Robert L. Grossman,
- Tudor Groza,
- Jaime M. Guidry Auvil,
- Roderic Guigó,
- Dipayan Gupta,
- Melissa A. Haendel,
- Ada Hamosh,
- David P. Hansen,
- Reece K. Hart,
- Dean Mitchell Hartley,
- David Haussler,
- Rachele M. Hendricks-Sturrup,
- Calvin W.L. Ho,
- Ashley E. Hobb,
- Michael M. Hoffman,
- Oliver M. Hofmann,
- Petr Holub,
- Jacob Shujui Hsu,
- Jean-Pierre Hubaux,
- Sarah E. Hunt,
- Ammar Husami,
- Julius O. Jacobsen,
- Saumya S. Jamuar,
- Elizabeth L. Janes,
- Francis Jeanson,
- Aina Jené,
- Amber L. Johns,
- Yann Joly,
- Steven J.M. Jones,
- Alexander Kanitz,
- Kazuto Kato,
- Thomas M. Keane,
- Kristina Kekesi-Lafrance,
- Jerome Kelleher,
- Giselle Kerry,
- Seik-Soon Khor,
- Bartha M. Knoppers,
- Melissa A. Konopko,
- Kenjiro Kosaki,
- Martin Kuba,
- Jonathan Lawson,
- Rasko Leinonen,
- Stephanie Li,
- Michael F. Lin,
- Mikael Linden,
- Xianglin Liu,
- Isuru Udara Liyanage,
- Javier Lopez,
- Anneke M. Lucassen,
- Michael Lukowski,
- Alice L. Mann,
- John Marshall,
- Michele Mattioni,
- Alejandro Metke-Jimenez,
- Anna Middleton,
- Richard J. Milne,
- Fruzsina Molnár-Gábor,
- Nicola Mulder,
- Monica C. Munoz-Torres,
- Rishi Nag,
- Hidewaki Nakagawa,
- Jamal Nasir,
- Arcadi Navarro,
- Tristan H. Nelson,
- Ania Niewielska,
- Amy Nisselle,
- Jeffrey Niu,
- Tommi H. Nyrönen,
- Brian D. O’Connor,
- Sabine Oesterle,
- Soichi Ogishima,
- Vivian Ota Wang,
- Laura A.D. Paglione,
- Emilio Palumbo,
- Helen E. Parkinson,
- Anthony A. Philippakis,
- Angel D. Pizarro,
- Andreas Prlic,
- Jordi Rambla,
- Augusto Rendon,
- Renee A. Rider,
- Peter N. Robinson,
- Kurt W. Rodarmer,
- Laura Lyman Rodriguez,
- Alan F. Rubin,
- Manuel Rueda,
- Gregory A. Rushton,
- Rosalyn S. Ryan,
- Gary I. Saunders,
- Helen Schuilenburg,
- Torsten Schwede,
- Serena Scollen,
- Alexander Senf,
- Nathan C. Sheffield,
- Neerjah Skantharajah,
- Albert V. Smith,
- Heidi J. Sofia,
- Dylan Spalding,
- Amanda B. Spurdle,
- Zornitza Stark,
- Lincoln D. Stein,
- Makoto Suematsu,
- Patrick Tan,
- Jonathan A. Tedds,
- Alastair A. Thomson,
- Adrian Thorogood,
- Timothy L. Tickle,
- Katsushi Tokunaga,
- Juha Törnroos,
- David Torrents,
- Sean Upchurch,
- Alfonso Valencia,
- Roman Valls Guimera,
- Jessica Vamathevan,
- Susheel Varma,
- Danya F. Vears,
- Coby Viner,
- Craig Voisin,
- Alex H. Wagner,
- Susan E. Wallace,
- Brian P. Walsh,
- Marc S. Williams,
- Eva C. Winkler,
- Barbara J. Wold,
- Grant M. Wood,
- J. Patrick Woolley,
- Chisato Yamasaki,
- Andrew D. Yates,
- Christina K. Yung,
- Lyndon J. Zass,
- Ksenia Zaytseva,
- Junjun Zhang,
- Peter Goodhand,
- Kathryn North,
- Ewan Birney
Affiliations
- Heidi L. Rehm
- Broad Institute of MIT and Harvard, Cambridge, MA, USA; Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA
- Angela J.H. Page
- Broad Institute of MIT and Harvard, Cambridge, MA, USA; Global Alliance for Genomics and Health, Toronto, ON, Canada; Corresponding author
- Lindsay Smith
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Jeremy B. Adams
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Gil Alterovitz
- Brigham and Women’s Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA
- Lawrence J. Babb
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Maxmillian P. Barkley
- DNAstack, Toronto, ON, Canada
- Michael Baudis
- University of Zurich, Zurich, Switzerland; SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland
- Michael J.S. Beauvais
- Global Alliance for Genomics and Health, Toronto, ON, Canada; McGill University, Montreal, QC, Canada
- Tim Beck
- University of Leicester, Leicester, UK
- Jacques S. Beckmann
- University of Lausanne, Lausanne, Switzerland
- Sergi Beltran
- CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain
- David Bernick
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Alexander Bernier
- McGill University, Montreal, QC, Canada
- James K. Bonfield
- Wellcome Sanger Institute, Hinxton, UK
- Tiffany F. Boughtwood
- Australian Genomics, Parkville, VIC, Australia; Murdoch Children’s Research Institute, Parkville, VIC, Australia
- Guillaume Bourque
- McGill University, Montreal, QC, Canada; Canadian Center for Computational Genomics, Montreal, QC, Canada
- Sarion R. Bowers
- Wellcome Sanger Institute, Hinxton, UK
- Anthony J. Brookes
- University of Leicester, Leicester, UK
- Michael Brudno
- Canadian Center for Computational Genomics, Montreal, QC, Canada; University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada; Vector Institute, Toronto, ON, Canada; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada
- Matthew H. Brush
- Oregon Health and Science University, Portland, OR, USA
- David Bujold
- McGill University, Montreal, QC, Canada; Canadian Center for Computational Genomics, Montreal, QC, Canada; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada
- Tony Burdett
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Orion J. Buske
- PhenoTips, Toronto, ON, Canada
- Moran N. Cabili
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Daniel L. Cameron
- Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia
- Robert J. Carroll
- Vanderbilt University Medical Center, Nashville, TN, USA
- Esmeralda Casas-Silva
- Kelly Government Solutions, Rockville, MD, USA
- Debyani Chakravarty
- Memorial Sloan Kettering Cancer Center, New York, NY, USA
- Bimal P. Chaudhari
- Nationwide Children’s Hospital, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA
- Shu Hui Chen
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
- J. Michael Cherry
- Stanford University, Stanford, CA, USA
- Justina Chung
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Melissa Cline
- UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA
- Hayley L. Clissold
- Wellcome Sanger Institute, Hinxton, UK
- Robert M. Cook-Deegan
- Arizona State University, Washington, DC, USA
- Mélanie Courtot
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Fiona Cunningham
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Miro Cupak
- DNAstack, Toronto, ON, Canada
- Robert M. Davies
- Wellcome Sanger Institute, Hinxton, UK
- Danielle Denisko
- University of Toronto, Toronto, ON, Canada
- Megan J. Doerr
- Sage Bionetworks, Seattle, WA, USA
- Lena I. Dolman
- University of Toronto, Toronto, ON, Canada
- Edward S. Dove
- University of Edinburgh, Edinburgh, UK
- L. Jonathan Dursi
- University Health Network, Toronto, ON, Canada; Canadian Distributed Infrastructure for Genomics (CanDIG), Toronto, ON, Canada
- Stephanie O.M. Dyke
- McGill University, Montreal, QC, Canada
- James A. Eddy
- Sage Bionetworks, Seattle, WA, USA
- Karen Eilbeck
- University of Utah, Salt Lake City, UT, USA
- Kyle P. Ellrott
- Oregon Health and Science University, Portland, OR, USA
- Susan Fairley
- Global Alliance for Genomics and Health, Toronto, ON, Canada; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Khalid A. Fakhro
- Sidra Medicine, Doha, Qatar; Weill Cornell Medicine - Qatar, Doha, Qatar
- Helen V. Firth
- Wellcome Sanger Institute, Hinxton, UK; Addenbrooke’s Hospital, Cambridge, UK
- Michael S. Fitzsimons
- University of Chicago, Chicago, IL, USA
- Marc Fiume
- DNAstack, Toronto, ON, Canada
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Ian M. Fore
- National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
- Mallory A. Freeberg
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Robert R. Freimuth
- Mayo Clinic, Rochester, MN, USA
- Lauren A. Fromont
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Jonathan Fuerth
- DNAstack, Toronto, ON, Canada
- Clara L. Gaff
- Australian Genomics, Parkville, VIC, Australia; Murdoch Children’s Research Institute, Parkville, VIC, Australia; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia
- Weiniu Gan
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
- Elena M. Ghanaim
- National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
- David Glazer
- Verily Life Sciences, South San Francisco, CA, USA
- Robert C. Green
- Brigham and Women’s Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA
- Malachi Griffith
- Washington University School of Medicine in St. Louis, St. Louis, MO, USA
- Obi L. Griffith
- Washington University School of Medicine in St. Louis, St. Louis, MO, USA
- Robert L. Grossman
- University of Chicago, Chicago, IL, USA
- Tudor Groza
- Pryzm Health, Sydney, QLD, Australia
- Jaime M. Guidry Auvil
- National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
- Roderic Guigó
- Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Dipayan Gupta
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Melissa A. Haendel
- University of Colorado Anschutz Medical Campus, Aurora, CO, USA
- Ada Hamosh
- Johns Hopkins University, Baltimore, MD, USA
- David P. Hansen
- Australian Genomics, Parkville, VIC, Australia; The Australian e-Health Research Centre, CSIRO, Herston, QLD, Australia
- Reece K. Hart
- Broad Institute of MIT and Harvard, Cambridge, MA, USA; Invitae, San Francisco, CA, USA; MyOme, Inc, San Bruno, CA, USA
- Dean Mitchell Hartley
- Autism Speaks, Princeton, NJ, USA
- David Haussler
- UC Santa Cruz Genomics Institute, Santa Cruz, CA, USA; Howard Hughes Medical Institute, University of California, Santa Cruz, CA, USA
- Rachele M. Hendricks-Sturrup
- Duke-Margolis Center for Health Policy, Washington, DC, USA
- Calvin W.L. Ho
- The University of Hong Kong, Hong Kong, Hong Kong
- Ashley E. Hobb
- DNAstack, Toronto, ON, Canada
- Michael M. Hoffman
- University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada; Vector Institute, Toronto, ON, Canada
- Oliver M. Hofmann
- University of Toronto, Toronto, ON, Canada; University of Melbourne, Melbourne, VIC, Australia
- Petr Holub
- BBMRI-ERIC, Graz, Austria; Masaryk University, Brno, Czech Republic
- Jacob Shujui Hsu
- National Taiwan University, Taipei City, Taiwan
- Jean-Pierre Hubaux
- École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Sarah E. Hunt
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Ammar Husami
- Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
- Julius O. Jacobsen
- Queen Mary University of London, London, UK
- Saumya S. Jamuar
- SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Republic of Singapore
- Elizabeth L. Janes
- Global Alliance for Genomics and Health, Toronto, ON, Canada; University of Waterloo, Waterloo, ON, Canada
- Francis Jeanson
- Datadex Inc., Toronto, ON, Canada
- Aina Jené
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Amber L. Johns
- Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
- Yann Joly
- McGill University, Montreal, QC, Canada
- Steven J.M. Jones
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada
- Alexander Kanitz
- SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University of Basel, Basel, Switzerland
- Kazuto Kato
- Osaka University, Suita, Japan
- Thomas M. Keane
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK; University of Nottingham, Nottingham, UK
- Kristina Kekesi-Lafrance
- Global Alliance for Genomics and Health, Toronto, ON, Canada; McGill University, Montreal, QC, Canada
- Jerome Kelleher
- University of Oxford, Oxford, UK
- Giselle Kerry
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Seik-Soon Khor
- National Center for Global Health and Medicine Hospital, Tokyo, Japan; University of Tokyo, Tokyo, Japan
- Bartha M. Knoppers
- McGill University, Montreal, QC, Canada
- Melissa A. Konopko
- ELIXIR Hub, Hinxton, UK
- Kenjiro Kosaki
- Keio University School of Medicine, Tokyo, Japan
- Martin Kuba
- Masaryk University, Brno, Czech Republic
- Jonathan Lawson
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Rasko Leinonen
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Stephanie Li
- Broad Institute of MIT and Harvard, Cambridge, MA, USA; Global Alliance for Genomics and Health, Toronto, ON, Canada
- Michael F. Lin
- mlin.net LLC, San Jose, CA, USA
- Mikael Linden
- CSC–IT Center for Science, Espoo, Finland; ELIXIR Finland, Espoo, Finland
- Xianglin Liu
- University of Waterloo, Waterloo, ON, Canada
- Isuru Udara Liyanage
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Javier Lopez
- Genomics England, London, UK
- Anneke M. Lucassen
- Faculty of Medicine, University Southampton, Southampton, UK
- Michael Lukowski
- University of Chicago, Chicago, IL, USA
- Alice L. Mann
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Wellcome Sanger Institute, Hinxton, UK
- John Marshall
- University of Glasgow, Glasgow, UK
- Michele Mattioni
- Seven Bridges, Boston, MA, USA
- Alejandro Metke-Jimenez
- The Australian e-Health Research Centre, CSIRO, Herston, QLD, Australia
- Anna Middleton
- Wellcome Connecting Science, Hinxton, UK; University of Cambridge, Cambridge, UK
- Richard J. Milne
- Wellcome Connecting Science, Hinxton, UK; University of Cambridge, Cambridge, UK
- Fruzsina Molnár-Gábor
- Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany
- Nicola Mulder
- H3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa
- Monica C. Munoz-Torres
- University of Colorado Anschutz Medical Campus, Aurora, CO, USA
- Rishi Nag
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Hidewaki Nakagawa
- Japan Agency for Medical Research & Development (AMED), Tokyo, Japan; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- Jamal Nasir
- University of Northampton, Northampton, UK
- Arcadi Navarro
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu Fabra (UPF), Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain; Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain
- Tristan H. Nelson
- Genomic Medicine Institute, Geisinger, Danville, PA, USA
- Ania Niewielska
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Amy Nisselle
- Murdoch Children’s Research Institute, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Human Genetics Society of Australasia Education, Ethics & Social Issues Committee, Alexandria, NSW, Australia
- Jeffrey Niu
- University Health Network, Toronto, ON, Canada
- Tommi H. Nyrönen
- CSC–IT Center for Science, Espoo, Finland; ELIXIR Finland, Espoo, Finland
- Brian D. O’Connor
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Sabine Oesterle
- SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland
- Soichi Ogishima
- Tohoku University, Sendai, Japan
- Vivian Ota Wang
- National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
- Laura A.D. Paglione
- Spherical Cow Group, New York, NY, USA; Laura Paglione LLC, New York, NY, USA
- Emilio Palumbo
- Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Helen E. Parkinson
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Anthony A. Philippakis
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Angel D. Pizarro
- Amazon Web Services, Inc., Seattle, WA, USA
- Andreas Prlic
- Invitae, San Francisco, CA, USA
- Jordi Rambla
- Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Augusto Rendon
- Genomics England, London, UK
- Renee A. Rider
- National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
- Peter N. Robinson
- The Jackson Laboratory, Farmington, CT, USA; University of Connecticut, Farmington, CT, USA
- Kurt W. Rodarmer
- National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA
- Laura Lyman Rodriguez
- Patient-Centered Outcomes Research Institute (PCORI), Washington, DC, USA
- Alan F. Rubin
- Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia
- Manuel Rueda
- Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain
- Gregory A. Rushton
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Rosalyn S. Ryan
- Bicgen Foundation Inc, Arlington Heights, IL, USA
- Gary I. Saunders
- ELIXIR Hub, Hinxton, UK
- Helen Schuilenburg
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Torsten Schwede
- SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland; University of Basel, Basel, Switzerland
- Serena Scollen
- ELIXIR Hub, Hinxton, UK
- Alexander Senf
- Congenica Ltd., Cambridge, UK
- Nathan C. Sheffield
- University of Virginia, Charlottesville, VA, USA
- Neerjah Skantharajah
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Albert V. Smith
- University of Michigan, Ann Arbor, MI, USA
- Heidi J. Sofia
- National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
- Dylan Spalding
- CSC–IT Center for Science, Espoo, Finland; ELIXIR Finland, Espoo, Finland
- Amanda B. Spurdle
- QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
- Zornitza Stark
- Australian Genomics, Parkville, VIC, Australia; Murdoch Children’s Research Institute, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia
- Lincoln D. Stein
- Ontario Institute for Cancer Research, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada
- Makoto Suematsu
- Keio University School of Medicine, Tokyo, Japan
- Patrick Tan
- SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Republic of Singapore; Precision Health Research Singapore, Singapore, Republic of Singapore; Genome Institute of Singapore, Singapore, Republic of Singapore
- Jonathan A. Tedds
- ELIXIR Hub, Hinxton, UK
- Alastair A. Thomson
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
- Adrian Thorogood
- McGill University, Montreal, QC, Canada; University of Luxembourg, Esch-sur-Alzette, Luxembourg
- Timothy L. Tickle
- Broad Institute of MIT and Harvard, Cambridge, MA, USA
- Katsushi Tokunaga
- University of Tokyo, Tokyo, Japan; National Center for Global Health and Medicine, Tokyo, Japan
- Juha Törnroos
- CSC–IT Center for Science, Espoo, Finland; ELIXIR Finland, Espoo, Finland
- David Torrents
- Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain; Barcelona Supercomputing Center, Barcelona, Spain
- Sean Upchurch
- California Institute of Technology, Pasadena, CA, USA
- Alfonso Valencia
- Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain; Barcelona Supercomputing Center, Barcelona, Spain
- Roman Valls Guimera
- University of Melbourne, Melbourne, VIC, Australia
- Jessica Vamathevan
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Susheel Varma
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK; Health Data Research UK, London, UK
- Danya F. Vears
- Murdoch Children’s Research Institute, Parkville, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Human Genetics Society of Australasia Education, Ethics & Social Issues Committee, Alexandria, NSW, Australia; Melbourne Law School, University of Melbourne, Parkville, VIC, Australia
- Coby Viner
- University of Toronto, Toronto, ON, Canada; University Health Network, Toronto, ON, Canada
- Craig Voisin
- Google LLC, Kitchener, ON, Canada
- Alex H. Wagner
- Nationwide Children’s Hospital, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA
- Susan E. Wallace
- University of Leicester, Leicester, UK
- Brian P. Walsh
- Oregon Health and Science University, Portland, OR, USA
- Marc S. Williams
- Genomic Medicine Institute, Geisinger, Danville, PA, USA
- Eva C. Winkler
- Section of Translational Medical Ethics, University Hospital Heidelberg, Heidelberg, Germany
- Barbara J. Wold
- California Institute of Technology, Pasadena, CA, USA
- Grant M. Wood
- Salt Lake City, UT, USA
- J. Patrick Woolley
- University of Oxford, Oxford, UK
- Chisato Yamasaki
- Osaka University, Suita, Japan
- Andrew D. Yates
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK
- Christina K. Yung
- Ontario Institute for Cancer Research, Toronto, ON, Canada; Indoc Research, Toronto, ON, Canada
- Lyndon J. Zass
- H3ABioNet, Computational Biology Division, IDM, Faculty of Health Sciences, Cape Town, South Africa
- Ksenia Zaytseva
- McGill University, Montreal, QC, Canada; Canadian Centre for Computational Genomics, Montreal, QC, Canada
- Junjun Zhang
- Ontario Institute for Cancer Research, Toronto, ON, Canada
- Peter Goodhand
- Global Alliance for Genomics and Health, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada
- Kathryn North
- Murdoch Children’s Research Institute, Parkville, VIC, Australia; University of Toronto, Toronto, ON, Canada; University of Melbourne, Melbourne, VIC, Australia
- Ewan Birney
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK; European Molecular Biology Laboratory, Heidelberg, Germany
- Journal volume & issue
-
Vol. 1,
no. 2
p. 100029
Abstract
Summary: The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.
