Nature Communications (Jan 2022)
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease
- Yun Yang,
- Victor Tapias,
- Diana Acosta,
- Hui Xu,
- Huanlian Chen,
- Ruchika Bhawal,
- Elizabeth T. Anderson,
- Elena Ivanova,
- Hening Lin,
- Botir T. Sagdullaev,
- Jianer Chen,
- William L. Klein,
- Kirsten L. Viola,
- Sam Gandy,
- Vahram Haroutunian,
- M. Flint Beal,
- David Eliezer,
- Sheng Zhang,
- Gary E. Gibson
Affiliations
- Yun Yang
- Integrated Medicine Research Center for Neurological Rehabilitation, College of Medicine, Jiaxing University
- Victor Tapias
- Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
- Diana Acosta
- Department of Biochemistry, Weill Cornell Medicine
- Hui Xu
- Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
- Huanlian Chen
- Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
- Ruchika Bhawal
- Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University
- Elizabeth T. Anderson
- Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University
- Elena Ivanova
- Imaging Core, Burke Neurological Institute
- Hening Lin
- Department of Chemistry and Chemical Biology, Cornell University
- Botir T. Sagdullaev
- Ophthalmology and Neuroscience, Weill Cornell Medicine
- Jianer Chen
- Integrated Medicine Research Center for Neurological Rehabilitation, College of Medicine, Jiaxing University
- William L. Klein
- Department of Neurobiology, Northwestern University
- Kirsten L. Viola
- Department of Neurobiology, Northwestern University
- Sam Gandy
- Department of Neurology and Mount Sinai Center for Cognitive Health and NFL Neurological Center, Icahn School of Medicine at Mount Sinai
- Vahram Haroutunian
- Department of Psychiatry Icahn School of Medicine at Mount Sinai
- M. Flint Beal
- Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
- David Eliezer
- Department of Biochemistry, Weill Cornell Medicine
- Sheng Zhang
- Proteomics and Metabolomics Facility, Institute of Biotechnology, Cornell University
- Gary E. Gibson
- Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-021-27572-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
