Metabolites (Aug 2018)
Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics
- Ville Mikael Koistinen,
- Andreia Bento da Silva,
- László Abrankó,
- Dorrain Low,
- Rocio Garcia Villalba,
- Francisco Tomás Barberán,
- Rikard Landberg,
- Otto Savolainen,
- Inmaculada Alvarez-Acero,
- Sonia de Pascual-Teresa,
- Christof Van Poucke,
- Conceição Almeida,
- Lucie Petrásková,
- Kateřina Valentová,
- Stephanie Durand,
- Wiesław Wiczkowski,
- Dorota Szawara-Nowak,
- Raúl González-Domínguez,
- Rafael Llorach,
- Cristina Andrés-Lacueva,
- Anna-Marja Aura,
- Tuulikki Seppänen-Laakso,
- Kati Hanhineva,
- Claudine Manach,
- Maria Rosário Bronze
Affiliations
- Ville Mikael Koistinen
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
- Andreia Bento da Silva
- Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa (ITQB NOVA), Av. da República, 2780-157 Oeiras, Portugal
- László Abrankó
- Alkalmazott Kemia Tsz, Elelmiszertudomanyi Kar, Szent István Egyetem, 29-43 Villanyi Street, 1118 Budapest, Hungary
- Dorrain Low
- INRA, Human Nutrition Unit, Université Clermont Auvergne, F63000 Clermont-Ferrand, France
- Rocio Garcia Villalba
- Department of Food Science and Technology, CEBAS-CSIC, Campus Universitario de Espinardo, edf 25, 30100 Murcia, Spain
- Francisco Tomás Barberán
- Department of Food Science and Technology, CEBAS-CSIC, Campus Universitario de Espinardo, edf 25, 30100 Murcia, Spain
- Rikard Landberg
- Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden
- Otto Savolainen
- Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden
- Inmaculada Alvarez-Acero
- Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 10, 28040 Madrid, Spain
- Sonia de Pascual-Teresa
- Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jose Antonio Novais 10, 28040 Madrid, Spain
- Christof Van Poucke
- Technology and Food Science Department, Flanders Research Institute for Agriculture Fisheries and Food (ILVO), Brusselsesteenweg 370, B-9090 Melle, Belgium
- Conceição Almeida
- Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa (ITQB NOVA), Av. da República, 2780-157 Oeiras, Portugal
- Lucie Petrásková
- Laboratory of Biotransformation, Institute of Microbiology of the CAS, Vídeňská 1083, CZ-142 20 Prague, Czechia
- Kateřina Valentová
- Laboratory of Biotransformation, Institute of Microbiology of the CAS, Vídeňská 1083, CZ-142 20 Prague, Czechia
- Stephanie Durand
- INRA, Human Nutrition Unit, Université Clermont Auvergne, F63000 Clermont-Ferrand, France
- Wiesław Wiczkowski
- Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland
- Dorota Szawara-Nowak
- Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland
- Raúl González-Domínguez
- Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s/n, 08028 Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, Barcelona, Spain;
- Rafael Llorach
- Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s/n, 08028 Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, Barcelona, Spain;
- Cristina Andrés-Lacueva
- Department of Nutrition, Food Science and Gastronomy, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, s/n, 08028 Barcelona, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Salud Carlos III, Barcelona, Spain;
- Anna-Marja Aura
- VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 VTT, Espoo, Finland
- Tuulikki Seppänen-Laakso
- VTT Technical Research Centre of Finland Ltd., P.O. Box 1000, FI-02044 VTT, Espoo, Finland
- Kati Hanhineva
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland
- Claudine Manach
- INRA, Human Nutrition Unit, Université Clermont Auvergne, F63000 Clermont-Ferrand, France
- Maria Rosário Bronze
- Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa (ITQB NOVA), Av. da República, 2780-157 Oeiras, Portugal
- DOI
- https://doi.org/10.3390/metabo8030046
- Journal volume & issue
-
Vol. 8,
no. 3
p. 46
Abstract
Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.
Keywords
