Frontiers in Neurology (Oct 2024)
Admission albumin-globulin ratio associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage
- Xiumei Guo,
- Xiumei Guo,
- Xiumei Guo,
- Yu Xiong,
- Yu Xiong,
- Wen Gao,
- Wen Gao,
- Wen Gao,
- Xinyue Huang,
- Xinyue Huang,
- Hanlin Zheng,
- Hanlin Zheng,
- Huiqiang Wu,
- Huiqiang Wu,
- Xutang Jiang,
- Xutang Jiang,
- Qingxin Lin,
- Qingxin Lin,
- Yinfeng Xiao,
- Yinfeng Xiao,
- Qiaoling Liu,
- Zhigang Pan,
- Zhigang Pan,
- Chunhui Chen,
- Chunhui Chen,
- Weipeng Hu,
- Weipeng Hu,
- Pantelis Stavrinou,
- Pantelis Stavrinou,
- Aihua Liu,
- Aihua Liu,
- Lingxing Wang,
- Lingxing Wang,
- Feng Zheng,
- Feng Zheng
Affiliations
- Xiumei Guo
- Department of Neurology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xiumei Guo
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xiumei Guo
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Yu Xiong
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Yu Xiong
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Wen Gao
- Department of Neurology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Wen Gao
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Wen Gao
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xinyue Huang
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xinyue Huang
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Hanlin Zheng
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Hanlin Zheng
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Huiqiang Wu
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Huiqiang Wu
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xutang Jiang
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Xutang Jiang
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Qingxin Lin
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Qingxin Lin
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Yinfeng Xiao
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Yinfeng Xiao
- Department of Clinical Laboratory, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- Qiaoling Liu
- Department of Clinical Laboratory, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- Zhigang Pan
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Zhigang Pan
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Chunhui Chen
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Chunhui Chen
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Weipeng Hu
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Weipeng Hu
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Pantelis Stavrinou
- Department of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany
- Pantelis Stavrinou
- Neurosurgery, Metropolitan Hospital, Athens, Greece
- Aihua Liu
- Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Aihua Liu
- Department of Neurosurgery, Ningxia Hui Autonomous Region People's Hospital, Yinchuan, China
- Lingxing Wang
- Department of Neurology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Lingxing Wang
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Feng Zheng
- Department of Neurosurgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- Feng Zheng
- Medical Center for Neurological Disorders, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, China
- DOI
- https://doi.org/10.3389/fneur.2024.1438728
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundDespite the widespread use in ischemic stroke, cancer, and malnutrition, the predictive ability of serum albumin to globulin ratio (A/G) among patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. This study aimed to determine if serum A/G ratio is associated with the occurrence of delayed cerebral ischemia (DCI) after aSAH.MethodsWe retrospectively viewed the medical records of aSAH patients from 08/2017 to 08/2022. Serum albumin and globulin laboratory test results were collected within 24 hours after admission. Serum A/G were dichotomized based on whether the DCI occurred. Logistic regression was used to determine the predictors of DCI. The relationship between serum A/G and the occurrence of DCI was analyzed with receiver operating characteristic(ROC) curve.ResultsA total of 363 eligible patients with aSAH were included in the study, among which DCI occurred in 87 patients(23.97%). Serum A/G[OR=2.720, 95%CI (1.190-6.270), P=0.018], non-surgical[OR=0.228, 95%CI (0.065-0.621), P=0.008], lactate dehydrogenase[OR=1.004, 95%CI (1.000-1.008), P=0.029], P[OR=0.354, 95%CI (0.130-0.926), P=0.038], plasma fibrinogen[OR=1.266, 95%CI (1.019-1.583), P=0.035] were associated with the occurrence of DCI. ROC showed that serum A/G, non-surgical, LDH, P, plasma fibrinogen could predict the occurrence of DCI in aSAH patients with values 0.575, 0.560, 0.602, 0.571 and 0.539 for serum A/G, non-surgical, LDH, P, plasma fibrinogen, respectively.ConclusionsIn conclusion, serum A/G levels are correlated with DCI in individuals with aSAH, and high serum A/G levels on admission may be associated with the occurrence of DCI.
Keywords
- aneurysmal subarachnoid hemorrhage
- delayed cerebral ischemia
- serum albumin to globulin ratio
- lactate dehydrogenase
- phosphorous
- plasma fibrinogen