Frontiers in Neurology (Oct 2024)

Admission albumin-globulin ratio associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage

  • Xiumei Guo,
  • Xiumei Guo,
  • Xiumei Guo,
  • Yu Xiong,
  • Yu Xiong,
  • Wen Gao,
  • Wen Gao,
  • Wen Gao,
  • Xinyue Huang,
  • Xinyue Huang,
  • Hanlin Zheng,
  • Hanlin Zheng,
  • Huiqiang Wu,
  • Huiqiang Wu,
  • Xutang Jiang,
  • Xutang Jiang,
  • Qingxin Lin,
  • Qingxin Lin,
  • Yinfeng Xiao,
  • Yinfeng Xiao,
  • Qiaoling Liu,
  • Zhigang Pan,
  • Zhigang Pan,
  • Chunhui Chen,
  • Chunhui Chen,
  • Weipeng Hu,
  • Weipeng Hu,
  • Pantelis Stavrinou,
  • Pantelis Stavrinou,
  • Aihua Liu,
  • Aihua Liu,
  • Lingxing Wang,
  • Lingxing Wang,
  • Feng Zheng,
  • Feng Zheng

DOI
https://doi.org/10.3389/fneur.2024.1438728
Journal volume & issue
Vol. 15

Abstract

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BackgroundDespite the widespread use in ischemic stroke, cancer, and malnutrition, the predictive ability of serum albumin to globulin ratio (A/G) among patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. This study aimed to determine if serum A/G ratio is associated with the occurrence of delayed cerebral ischemia (DCI) after aSAH.MethodsWe retrospectively viewed the medical records of aSAH patients from 08/2017 to 08/2022. Serum albumin and globulin laboratory test results were collected within 24 hours after admission. Serum A/G were dichotomized based on whether the DCI occurred. Logistic regression was used to determine the predictors of DCI. The relationship between serum A/G and the occurrence of DCI was analyzed with receiver operating characteristic(ROC) curve.ResultsA total of 363 eligible patients with aSAH were included in the study, among which DCI occurred in 87 patients(23.97%). Serum A/G[OR=2.720, 95%CI (1.190-6.270), P=0.018], non-surgical[OR=0.228, 95%CI (0.065-0.621), P=0.008], lactate dehydrogenase[OR=1.004, 95%CI (1.000-1.008), P=0.029], P[OR=0.354, 95%CI (0.130-0.926), P=0.038], plasma fibrinogen[OR=1.266, 95%CI (1.019-1.583), P=0.035] were associated with the occurrence of DCI. ROC showed that serum A/G, non-surgical, LDH, P, plasma fibrinogen could predict the occurrence of DCI in aSAH patients with values 0.575, 0.560, 0.602, 0.571 and 0.539 for serum A/G, non-surgical, LDH, P, plasma fibrinogen, respectively.ConclusionsIn conclusion, serum A/G levels are correlated with DCI in individuals with aSAH, and high serum A/G levels on admission may be associated with the occurrence of DCI.

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