An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9

Taiki Saito; Hirokazu Yagi; Chu-Wei Kuo; Kay-Hooi Khoo; Koichi Kato

doi:10.1038/s42003-022-03616-1

Communications Biology (Jul 2022)

An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9

Taiki Saito,
Hirokazu Yagi,
Chu-Wei Kuo,
Kay-Hooi Khoo,
Koichi Kato

Affiliations

Taiki Saito: Graduate School of Pharmaceutical Sciences, Nagoya City University
Hirokazu Yagi: Graduate School of Pharmaceutical Sciences, Nagoya City University
Chu-Wei Kuo: Institute of Biological Chemistry, Academia Sinica, 128
Kay-Hooi Khoo: Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences
Koichi Kato: Graduate School of Pharmaceutical Sciences, Nagoya City University

DOI: https://doi.org/10.1038/s42003-022-03616-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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A 29-amino acid sequence in the N-terminal domain of LAMP-1 promotes its Lewis X glycosylation and is embeddable to other proteins for Lewis X glycoengineering.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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