Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Jing Zhao; Huidan Lu; Danxia Xu; Ruiqi Sun; Chengyu Fang; Qiyu Zhao; Chang He; Yuwei Pan; Feng Xu; Tianan Jiang

doi:10.1080/02656736.2022.2093994

International Journal of Hyperthermia (Dec 2022)

Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Jing Zhao,
Huidan Lu,
Danxia Xu,
Ruiqi Sun,
Chengyu Fang,
Qiyu Zhao,
Chang He,
Yuwei Pan,
Feng Xu,
Tianan Jiang

Affiliations

Jing Zhao: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Huidan Lu: Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Danxia Xu: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Ruiqi Sun: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chengyu Fang: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Qiyu Zhao: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Chang He: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Yuwei Pan: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Feng Xu: Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Tianan Jiang: Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.1080/02656736.2022.2093994
Journal volume & issue: Vol. 39, no. 1
pp. 1026 – 1035

Abstract

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Objective Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer.Methods We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their use as a complementary agent for nsPEF treatment.Results Our results showed that neutrophil-mediated delivery of liposomal-gemcitabine (NE/Lip-GEM) efficiently inhibited the growth of pancreatic tumors in mice whose has been treated with incomplete nsPEF ablation.Conclusions The combination of nsPEF and NE/Lip-GEM may be a promising synergistic strategy for pancreatic cancer therapy.

Published in International Journal of Hyperthermia

ISSN: 0265-6736 (Print); 1464-5157 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.tandfonline.com/journals/ihyt

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