The importance of NT proBNP in hypertensive patients management for preventing heart failure

Irina Cuciureanu; Anamaria-Georgiana Avram; Maria Suzana Guberna; Cătălina Liliana Andrei; Crina-Julieta Sinescu

doi:10.37897/RMJ.2021.1.13

Romanian Medical Journal (Mar 2021)

The importance of NT proBNP in hypertensive patients management for preventing heart failure

Irina Cuciureanu,
Anamaria-Georgiana Avram,
Maria Suzana Guberna,
Cătălina Liliana Andrei,
Crina-Julieta Sinescu

Affiliations

Irina Cuciureanu: Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România; Clinica de Cardiologie a Spitalului Clinic de Urgenţă „Bagdasar-Arseni“, Bucureşti, România
Anamaria-Georgiana Avram: Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România; Clinica de Cardiologie a Spitalului Clinic de Urgenţă „Bagdasar-Arseni“, Bucureşti, România
Maria Suzana Guberna: Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România; Clinica de Cardiologie a Spitalului Clinic de Urgenţă „Bagdasar-Arseni“, Bucureşti, România
Cătălina Liliana Andrei: Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România; Clinica de Cardiologie a Spitalului Clinic de Urgenţă „Bagdasar-Arseni“, Bucureşti, România
Crina-Julieta Sinescu: Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România; Clinica de Cardiologie a Spitalului Clinic de Urgenţă „Bagdasar-Arseni“, Bucureşti, România

DOI: https://doi.org/10.37897/RMJ.2021.1.13
Journal volume & issue: Vol. 68, no. 1
pp. 71 – 76

Abstract

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Purpose. NT proBNP is routinely used in the diagnosis and prognosis of HF. The study aimed to determine whether the value of NT proBNP can be used in hypertensive patients to detect patients at risk of developing HF and whether in these patients medical management guided by NT proBNP can prevent the development of HF. Material and methods. We included 275 hypertensive patients who presented to the Bagdasar-Arseni Emergency Hospital for cardiological consultation for a period of 3 years. Patients diagnosed with heart failure or left ventricular systolic dysfunction and patients with symptoms of heart failure at enrollment were excluded. We divided the patients into 2 groups, a control group and an intervention group. Patients in the intervention group were managed according to the NT proBNP value, and patients in the control group received standard treatment. Results. The objectives pursued at 3 years were: diagnosis of heart failure, systolic or diastolic dysfunction of the left ventricle and hospitalization for cardiovascular pathology. After 3 years, in the control group there intervention group. In the control group, 51 patients (38.1%) were diagnosed with LV systolic dysfunction compared to 37 patients (26.2%) in the intervention group. Regarding diastolic LV dysfunction, in the control group there were 83 patients (61.9%), and in the intervention group there were 73 patients (51.8%). Also, the rate of hospitalizations for cardiovascular pathology was higher in the control group 47 patients (35.1%) compared to 27 patients (19.1%) in the intervention group. Discussions. Hypertensive patients in the intervention group, who were managed according to the NT proBNP value, had a lower incidence rate of heart failure, LV systolic or diastolic dysfunction, or hospitalizations for cardiovascular events than in the control group. Conclusions. The value of NT proBNP may be useful for detecting hypertensive patients at risk of developing HF, and NT proBNP-guided medical management may prevent or delay the onset of HF.

Published in Romanian Medical Journal

ISSN: 1220-5478 (Print); 2069-606X (Online)
Publisher: Amaltea Medical Publishing House
Country of publisher: Romania
LCC subjects: Medicine: Medicine (General); Medicine: Surgery
Website: https://rmj.com.ro/

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