A connectomic analysis of deep brain stimulation for treatment-resistant depression

Zhoule Zhu; Elizabeth Hubbard; Xinxia Guo; Daniel A.N. Barbosa; Abdul Malik Popal; Chengwei Cai; Hongjie Jiang; Zhe Zheng; Jingquan Lin; Wei Gao; Jianmin Zhang; Katrina Bartas; Desiree Macchia; Pieter Derdeyn; Casey H. Halpern; Helen S. Mayberg; Kevin T. Beier; Junming Zhu; Hemmings Wu

Brain Stimulation (Sep 2021)

A connectomic analysis of deep brain stimulation for treatment-resistant depression

Zhoule Zhu,
Elizabeth Hubbard,
Xinxia Guo,
Daniel A.N. Barbosa,
Abdul Malik Popal,
Chengwei Cai,
Hongjie Jiang,
Zhe Zheng,
Jingquan Lin,
Wei Gao,
Jianmin Zhang,
Katrina Bartas,
Desiree Macchia,
Pieter Derdeyn,
Casey H. Halpern,
Helen S. Mayberg,
Kevin T. Beier,
Junming Zhu,
Hemmings Wu

Affiliations

Zhoule Zhu: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Elizabeth Hubbard: Department of Physiology and Biophysics, University of California, Irvine, CA, 92697-4560, USA
Xinxia Guo: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Daniel A.N. Barbosa: Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA
Abdul Malik Popal: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Chengwei Cai: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Hongjie Jiang: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Zhe Zheng: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Jingquan Lin: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Wei Gao: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Jianmin Zhang: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China
Katrina Bartas: Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, CA, 92697-4560, USA
Desiree Macchia: Department of Physiology and Biophysics, University of California, Irvine, CA, 92697-4560, USA
Pieter Derdeyn: Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, CA, 92697-4560, USA
Casey H. Halpern: Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA
Helen S. Mayberg: Departments of Neurology and Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Kevin T. Beier: Department of Physiology and Biophysics, University of California, Irvine, CA, 92697-4560, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA, 92697-4560, USA; Department of Biomedical Engineering, University of California, Irvine, CA, 92697-4560, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, 92697-4560, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, 92697, USA; Corresponding author. University of California, 825 Health Sciences Road, Medical Sciences D335, Irvine, CA, 92617, USA.
Junming Zhu: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China; Corresponding author. No. 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009, China.
Hemmings Wu: Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China; Corresponding author. , No. 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009 , China

Journal volume & issue: Vol. 14, no. 5
pp. 1226 – 1233

Abstract

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Objective: Deep brain stimulation (DBS) has been used as a treatment of last resort for treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been proposed and tested clinically, but the underlying circuit mechanisms remain unclear. Uncovering white matter tracts (WMT) activated by DBS targets may provide crucial information about the circuit substrates mediating DBS efficacy in ameliorating TRD. Methods: We performed probabilistic tractography using diffusion magnetic resonance imaging datas from 100 healthy volunteers in Human Connectome Project datasets to analyze the structural connectivity patterns of stimulation targeting currently-used DBS target for TRD. We generated mean and binary fiber distribution maps and calculated the numbers of WMT streamlines in the dataset. Results: Probabilistic tracking results revealed that activation of distinct DBS targets demonstrated modulation of overlapping but considerably distinct pathways. DBS targets were categorized into 4 groups: Cortical, Striatal, Thalamic, and Medial Forebrain Bundle according to their main modulated WMT and brain areas. Our data also revealed that Brodmann area 10 and amygdala are hub structures that are associated with all DBS targets. Conclusions: Our results together suggest that the distinct mechanism of DBS targets implies individualized target selection and formulation in the future of DBS treatment for TRD. The modulation of Brodmann area 10 and amygdala may be critical for the efficacy of DBS-mediated treatment of TRD.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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