The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats

Abstract

Introduction Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). Material and methods Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl3 group was given 300 mg/kg body weight (BW) of AlCl3 intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. Results MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. Conclusions MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.

Keywords

• alzheimer’s disease (ad)
• mesenchymal stem cells (mscs)
• cognitive dysfunction
• ryr3 gene
• ca2+ homeostasis