Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling

Ruri Tsuneishi; Naoto Matsumoto; Misa Itaoka; Yuri Urai; Minami Kaneko; Natsumi Watanabe; Shou Takashima; Yoichi Seki; Takako Morimoto; Hiroyuki Sakagami; Yuki Miyamoto; Junji Yamauchi

Data in Brief (Dec 2017)

Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling

Ruri Tsuneishi,
Naoto Matsumoto,
Misa Itaoka,
Yuri Urai,
Minami Kaneko,
Natsumi Watanabe,
Shou Takashima,
Yoichi Seki,
Takako Morimoto,
Hiroyuki Sakagami,
Yuki Miyamoto,
Junji Yamauchi

Affiliations

Ruri Tsuneishi: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Naoto Matsumoto: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Misa Itaoka: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Yuri Urai: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Minami Kaneko: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Natsumi Watanabe: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Shou Takashima: Glycobiology Research Unit, The Noguchi Institute, Itabashi, Tokyo 173-0003, Japan
Yoichi Seki: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Takako Morimoto: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Hiroyuki Sakagami: Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan
Yuki Miyamoto: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan; Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan
Junji Yamauchi: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan; Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan; Correspondence to: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

Journal volume & issue: Vol. 15
pp. 234 – 239

Abstract

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Cytohesin-1 is the guanine-nucleotide exchange factor of Arf6, a small GTPase of Arf family, and participates in cellular morphological changes. Knockout mice of cytohesin-1 exhibit decreased myelination of neuronal axons in the peripheral nervous system (PNS) âPhosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2012) [1]â. Herein we provide the data regarding decreased phosphorylation levels of protein kinases involved in two major myelination-related kinase cascades in cytohesin-1 knockout mice. Keywords: Cytohesin-1, Myelination, Peripheral nervous system, Protein kinase, Signaling

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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