Nature Communications (Dec 2021)
GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1
- Lucia Balazova,
- Miroslav Balaz,
- Carla Horvath,
- Áron Horváth,
- Caroline Moser,
- Zuzana Kovanicova,
- Adhideb Ghosh,
- Umesh Ghoshdastider,
- Vissarion Efthymiou,
- Elke Kiehlmann,
- Wenfei Sun,
- Hua Dong,
- Lianggong Ding,
- Ez-Zoubir Amri,
- Pirjo Nuutila,
- Kirsi A. Virtanen,
- Tarja Niemi,
- Barbara Ukropcova,
- Jozef Ukropec,
- Pawel Pelczar,
- Thorsten Lamla,
- Bradford Hamilton,
- Heike Neubauer,
- Christian Wolfrum
Affiliations
- Lucia Balazova
- Institute of Food, Nutrition and Health, ETH Zürich
- Miroslav Balaz
- Institute of Food, Nutrition and Health, ETH Zürich
- Carla Horvath
- Institute of Food, Nutrition and Health, ETH Zürich
- Áron Horváth
- Biomechanics Laboratory, University Hospital Balgrist, University of Zurich
- Caroline Moser
- Institute of Food, Nutrition and Health, ETH Zürich
- Zuzana Kovanicova
- Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences
- Adhideb Ghosh
- Institute of Food, Nutrition and Health, ETH Zürich
- Umesh Ghoshdastider
- Institute of Food, Nutrition and Health, ETH Zürich
- Vissarion Efthymiou
- Institute of Food, Nutrition and Health, ETH Zürich
- Elke Kiehlmann
- Institute of Food, Nutrition and Health, ETH Zürich
- Wenfei Sun
- Institute of Food, Nutrition and Health, ETH Zürich
- Hua Dong
- Institute of Food, Nutrition and Health, ETH Zürich
- Lianggong Ding
- Institute of Food, Nutrition and Health, ETH Zürich
- Ez-Zoubir Amri
- Université Côte d’Azur, French National Centre for Scientific Research, Inserm, iBV
- Pirjo Nuutila
- Turku PET Centre, University of Turku
- Kirsi A. Virtanen
- Turku PET Centre, University of Turku
- Tarja Niemi
- Department of Surgery, Turku University Hospital
- Barbara Ukropcova
- Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences
- Jozef Ukropec
- Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences
- Pawel Pelczar
- Center for Transgenic Models, University of Basel
- Thorsten Lamla
- Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG
- Bradford Hamilton
- Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG
- Heike Neubauer
- Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG
- Christian Wolfrum
- Institute of Food, Nutrition and Health, ETH Zürich
- DOI
- https://doi.org/10.1038/s41467-021-27442-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1, and contributes to the regulation of glucose and energy metabolism.
