Royal Society Open Science (Mar 2022)
The HEV Ventilator: at the interface between particle physics and biomedical engineering
- Jan Buytaert,
- Paula Collins,
- Adam Abed Abud,
- Phil Allport,
- Antonio Pazos Álvarez,
- Kazuyoshi Akiba,
- Oscar Augusto de Aguiar Francisco,
- Aurelio Bay,
- Florian Bernard,
- Sophie Baron,
- Claudia Bertella,
- Josef X. Brunner,
- Themis Bowcock,
- Martine Buytaert-De Jode,
- Wiktor Byczynski,
- Ricardo De Carvalho,
- Victor Coco,
- Ruth Collins,
- Nikola Dikic,
- Nicolas Dousse,
- Bruce Dowd,
- Kārlis Dreimanis,
- Raphael Dumps,
- Paolo Durante,
- Walid Fadel,
- Stephen Farry,
- Antonio Fernàndez Prieto,
- Arturo Fernàndez Tèllez,
- Gordon Flynn,
- Vinicius Franco Lima,
- Raymond Frei,
- Abraham Gallas Torreira,
- Tonatiuh García Chàvez,
- Evangelos Gazis,
- Roberto Guida,
- Karol Hennessy,
- Andre Henriques,
- David Hutchcroft,
- Stefan Ilic,
- Artūrs Ivanovs,
- Aleksandar Jevtic,
- Emigdio Jimenez Dominguez,
- Christian Joram,
- Kacper Kapusniak,
- Edgar Lemos Cid,
- Jana Lindner,
- Rolf Lindner,
- M. Ivàn Martínez Hernàndez,
- Mirko Meboldt,
- Marko Milovanovic,
- Sylvain Mico,
- Johan Morant,
- Michel Morel,
- Georg Männel,
- Dónal Murray,
- Irina Nasteva,
- Niko Neufeld,
- Igor Neuhold,
- Francisco Pardo-Sobrino López,
- Eliseo Pèrez Trigo,
- Gonzalo Pichel Jallas,
- Edyta Pilorz,
- Lise Piquilloud,
- Xavier Pons,
- David Reiner,
- Hector David Règules Medel,
- Saul Rodríguez Ramírez,
- Mario Rodíguez Cahuantzi,
- Carl Roosens,
- Philipp Rostalski,
- Freek Sanders,
- Eric Saucet,
- Marianne Schmid Daners,
- Burkhard Schmidt,
- Patrick Schoettker,
- Rainer Schwemmer,
- Heinrich Schindler,
- Archana Sharma,
- Derick Sivakumaran,
- Christophe Sigaud,
- Vasilios Spitas,
- Nicola Steffen,
- Peter Svihra,
- Guillermo Tejeda Muñoz,
- Nikolaos Tachatos,
- Efstratios Tsolakis,
- Jan van Leemput,
- Laurence Vignaux,
- Francois Vasey,
- Hamish Woonton,
- Ken Wyllie
Affiliations
- Jan Buytaert
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Paula Collins
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Adam Abed Abud
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Phil Allport
- Particle Physics Group, School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT, UK
- Antonio Pazos Álvarez
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Kazuyoshi Akiba
- Nikhef National Institute for Subatomic Physics, Amsterdam 1098 XG, The Netherlands
- Oscar Augusto de Aguiar Francisco
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Aurelio Bay
- Institute of Physics, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
- Florian Bernard
- Institute of Physics, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
- Sophie Baron
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Claudia Bertella
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Josef X. Brunner
- Neosim AG, CH-7000 Chur, Switzerland
- Themis Bowcock
- Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE, UK
- Martine Buytaert-De Jode
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Wiktor Byczynski
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Ricardo De Carvalho
- Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland
- Victor Coco
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Ruth Collins
- Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
- Nikola Dikic
- Applied Physics Laboratory, Faculty of Electronic Engineering, University of Nis˘, Aleksandra Medvedeva 14, Nis˘ 18000, Serbia
- Nicolas Dousse
- Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland
- Bruce Dowd
- Prince of Wales Hospital, Randwick, New South Wales 2052, Australia
- Kārlis Dreimanis
- Centre of High-Energy Physics and Accelerator Technologies and Faculty of Computer Science and Information Technology, Riga Technical University, 1 Kalku Street, Riga LV-1658, Latvia
- Raphael Dumps
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Paolo Durante
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Walid Fadel
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Stephen Farry
- Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE, UK
- Antonio Fernàndez Prieto
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Arturo Fernàndez Tèllez
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Gordon Flynn
- Prince of Wales Hospital, Randwick, New South Wales 2052, Australia
- Vinicius Franco Lima
- Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE, UK
- Raymond Frei
- Institute of Physics, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
- Abraham Gallas Torreira
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Tonatiuh García Chàvez
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Evangelos Gazis
- National Technical University of Athens - NTUA, Zografou Campus, 15780 Athens, Greece
- Roberto Guida
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Karol Hennessy
- Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE, UK
- Andre Henriques
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- David Hutchcroft
- Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE, UK
- Stefan Ilic
- Applied Physics Laboratory, Faculty of Electronic Engineering, University of Nis˘, Aleksandra Medvedeva 14, Nis˘ 18000, Serbia
- Artūrs Ivanovs
- Centre of High-Energy Physics and Accelerator Technologies and Faculty of Computer Science and Information Technology, Riga Technical University, 1 Kalku Street, Riga LV-1658, Latvia
- Aleksandar Jevtic
- GZA Hospitals, 2018 Antwerp, Belgium
- Emigdio Jimenez Dominguez
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Christian Joram
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Kacper Kapusniak
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Edgar Lemos Cid
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Jana Lindner
- University of Applied Sciences Offenburg, 77652 Offenburg, Baden-Wuerttemberg, Germany
- Rolf Lindner
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- M. Ivàn Martínez Hernàndez
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Mirko Meboldt
- Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
- Marko Milovanovic
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Sylvain Mico
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Johan Morant
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Michel Morel
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Georg Männel
- Fraunhofer Research Institution for Individualized and Cell-based Medical Engineering (IMTE), 23562 Lübeck, Germany
- Dónal Murray
- Department of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK
- Irina Nasteva
- Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-972, Brazil
- Niko Neufeld
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Igor Neuhold
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Francisco Pardo-Sobrino López
- Anesthesiology-Reanimation and Pain Therapeutics Service, Lucus Augusti University Hospital, 27003 Lugo, Spain
- Eliseo Pèrez Trigo
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Gonzalo Pichel Jallas
- Instituto Galego de Física de Altas Enerxías (IGFAE), Universidade de Santiago de Compostela, Santiago de Compostela, 15782 Galicia, Spain
- Edyta Pilorz
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Lise Piquilloud
- Adult Intensive Care Unit, University Hospital and University of Lausanne, Lausanne, Switzerland
- Xavier Pons
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- David Reiner
- John Curtin School of Medical Research, Canberra, Australian Capital Territory 2600, Australia
- Hector David Règules Medel
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Saul Rodríguez Ramírez
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Mario Rodíguez Cahuantzi
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Carl Roosens
- GZA Hospitals, 2018 Antwerp, Belgium
- Philipp Rostalski
- Institute for Electrical Engineering in Medicine, University of Lübeck, 23562 Lübeck, Germany
- Freek Sanders
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Eric Saucet
- Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland
- Marianne Schmid Daners
- Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
- Burkhard Schmidt
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Patrick Schoettker
- Centre Hospitalier Universitaire Vaudois, Lausanne CH-1011, Switzerland
- Rainer Schwemmer
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Heinrich Schindler
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Archana Sharma
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Derick Sivakumaran
- Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
- Christophe Sigaud
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Vasilios Spitas
- National Technical University of Athens - NTUA, Zografou Campus, 15780 Athens, Greece
- Nicola Steffen
- Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
- Peter Svihra
- Department of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK
- Guillermo Tejeda Muñoz
- Facultad de Ciencias Físico Matemàticas, Benèmerita Universidad Autónoma de Puebla, Apartado Postal 165, 72000 Puebla, Pue., Mèxico
- Nikolaos Tachatos
- Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland
- Efstratios Tsolakis
- National Technical University of Athens - NTUA, Zografou Campus, 15780 Athens, Greece
- Jan van Leemput
- GZA Hospitals, 2018 Antwerp, Belgium
- Laurence Vignaux
- Cardio-Respiratory Units, Hôpital de La Tour, 1217 Meyrin, Switzerland
- Francois Vasey
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- Hamish Woonton
- Monash Health, Melbourne, Victoria 3168, Australia
- Ken Wyllie
- European Organization for Nuclear Research, Espl. des Particules 1, 1211 Meyrin, Geneva, Switzerland
- DOI
- https://doi.org/10.1098/rsos.211519
- Journal volume & issue
-
Vol. 9,
no. 3
Abstract
A high-quality, low-cost ventilator, dubbed HEV, has been developed by the particle physics community working together with biomedical engineers and physicians around the world. The HEV design is suitable for use both in and out of hospital intensive care units, provides a variety of modes and is capable of supporting spontaneous breathing and supplying oxygen-enriched air. An external air supply can be combined with the unit for use in situations where compressed air is not readily available. HEV supports remote training and post market surveillance via a Web interface and data logging to complement standard touch screen operation, making it suitable for a wide range of geographical deployment. The HEV design places emphasis on the ventilation performance, especially the quality and accuracy of the pressure curves, reactivity of the trigger, measurement of delivered volume and control of oxygen mixing, delivering a global performance which will be applicable to ventilator needs beyond the COVID-19 pandemic. This article describes the conceptual design and presents the prototype units together with a performance evaluation.
Keywords
