PEPD is a pivotal regulator of p53 tumor suppressor

Lu Yang; Yun Li; Arup Bhattacharya; Yuesheng Zhang

doi:10.1038/s41467-017-02097-9

Nature Communications (Dec 2017)

PEPD is a pivotal regulator of p53 tumor suppressor

Lu Yang,
Yun Li,
Arup Bhattacharya,
Yuesheng Zhang

Affiliations

Lu Yang: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute
Yun Li: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute
Arup Bhattacharya: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute
Yuesheng Zhang: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute

DOI: https://doi.org/10.1038/s41467-017-02097-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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p53 is a pivotal tumour suppressor that is activated by various cellular stress inducers. Here, the authors show that peptidase D (PEPD) promotes the growth of cancer cells by suppressing p53 and that the complex PEPD-p53 is critical for robust p53 activation in response to stress signals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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