Nature Communications (Jun 2017)
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception
- Frank Bicker,
- Verica Vasic,
- Guilherme Horta,
- Felipe Ortega,
- Hendrik Nolte,
- Atria Kavyanifar,
- Stefanie Keller,
- Nevenka Dudvarski Stankovic,
- Patrick N. Harter,
- Rui Benedito,
- Beat Lutz,
- Tobias Bäuerle,
- Jens Hartwig,
- Jan Baumgart,
- Marcus Krüger,
- Konstantin Radyushkin,
- Lavinia Alberi,
- Benedikt Berninger,
- Mirko H. H. Schmidt
Affiliations
- Frank Bicker
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Verica Vasic
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Guilherme Horta
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Felipe Ortega
- Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine
- Hendrik Nolte
- Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Atria Kavyanifar
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Stefanie Keller
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Nevenka Dudvarski Stankovic
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Patrick N. Harter
- Edinger-Institute (Neurological Institute), Goethe-University, School of Medicine
- Rui Benedito
- Molecular Genetics of Angiogenesis Laboratory, Centro Nacional de Investigaciones Cardiovasculares
- Beat Lutz
- Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine
- Tobias Bäuerle
- Preclinical Imaging Platform Erlangen, Institute of Radiology, University Medical Center Erlangen
- Jens Hartwig
- Institute for Molecular Biology, Johannes Gutenberg University
- Jan Baumgart
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Marcus Krüger
- Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne
- Konstantin Radyushkin
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- Lavinia Alberi
- Swiss Integrative Center for Human Health SA
- Benedikt Berninger
- Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine
- Mirko H. H. Schmidt
- Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg University, School of Medicine
- DOI
- https://doi.org/10.1038/ncomms15922
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The vascular stem cell niche regulates the proliferation and differentiation of neural stem cells (NSCs) in the adult subventricular zone. Here the authors identify EGFL7 as a neurovascular regulator of NSCsin vivo; EGFL7-knockout mice show reduced neurogenesis, and exhibit impaired olfactory perception and behaviour.
