Guillain–Barre syndrome-like presentation and thrombotic microangiopathy with calcineurin inhibitor - A case report

Abstract

A 35-year-old male, 3 months postrenal transplant, presented with acute-onset demyelinating polyneuropathy, diagnosed to have tacrolimus-associated Guillain–Barre syndrome. He recovered within 5–7 days after converting from tacrolimus to cyclosporine (CsA). He developed graft dysfunction after 2 months due to CsA-induced thrombotic microangiopathy. He responded after converting to sirolimus from CsA. The proper knowledge of immunosuppression side effect and its discontinuation in the early period prevents permanent damage.

Keywords

• cyclosporine
• guillain–barre syndrome
• thrombotic microangiopathy