Nature Communications (Nov 2017)
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
- Chris J. C. Johnston,
- Danielle J. Smyth,
- Ravindra B. Kodali,
- Madeleine P. J. White,
- Yvonne Harcus,
- Kara J. Filbey,
- James P. Hewitson,
- Cynthia S. Hinck,
- Alasdair Ivens,
- Andrea M. Kemter,
- Anna O. Kildemoes,
- Thierry Le Bihan,
- Dinesh C. Soares,
- Stephen M. Anderton,
- Thomas Brenn,
- Stephen J. Wigmore,
- Hannah V. Woodcock,
- Rachel C. Chambers,
- Andrew P. Hinck,
- Henry J. McSorley,
- Rick M. Maizels
Affiliations
- Chris J. C. Johnston
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Danielle J. Smyth
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Ravindra B. Kodali
- Department of Structural Biology, University of Pittsburgh School of Medicine
- Madeleine P. J. White
- Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow
- Yvonne Harcus
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Kara J. Filbey
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- James P. Hewitson
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Cynthia S. Hinck
- Department of Structural Biology, University of Pittsburgh School of Medicine
- Alasdair Ivens
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Andrea M. Kemter
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Anna O. Kildemoes
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Thierry Le Bihan
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Dinesh C. Soares
- MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh
- Stephen M. Anderton
- MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh
- Thomas Brenn
- Department of Pathology, Western General Hospital, University of Edinburgh
- Stephen J. Wigmore
- Department of Clinical Surgery, University of Edinburgh
- Hannah V. Woodcock
- Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London
- Rachel C. Chambers
- Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London
- Andrew P. Hinck
- Department of Structural Biology, University of Pittsburgh School of Medicine
- Henry J. McSorley
- Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
- Rick M. Maizels
- Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow
- DOI
- https://doi.org/10.1038/s41467-017-01886-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signalling and generate inducible regulatory T cells.
