The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma

Hidenori Machino; Syuzo Kaneko; Masaaki Komatsu; Noriko Ikawa; Ken Asada; Ryuichiro Nakato; Kanto Shozu; Ai Dozen; Kenbun Sone; Hiroshi Yoshida; Tomoyasu Kato; Katsutoshi Oda; Yutaka Osuga; Tomoyuki Fujii; Gottfried von Keudell; Vassiliki Saloura; Ryuji Hamamoto

doi:10.1038/s42003-021-02992-4

Communications Biology (Jan 2022)

The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma

Hidenori Machino,
Syuzo Kaneko,
Masaaki Komatsu,
Noriko Ikawa,
Ken Asada,
Ryuichiro Nakato,
Kanto Shozu,
Ai Dozen,
Kenbun Sone,
Hiroshi Yoshida,
Tomoyasu Kato,
Katsutoshi Oda,
Yutaka Osuga,
Tomoyuki Fujii,
Gottfried von Keudell,
Vassiliki Saloura,
Ryuji Hamamoto

Affiliations

Hidenori Machino: Division of Medical AI Research and Development, National Cancer Center Research Institute
Syuzo Kaneko: Division of Medical AI Research and Development, National Cancer Center Research Institute
Masaaki Komatsu: Division of Medical AI Research and Development, National Cancer Center Research Institute
Noriko Ikawa: Division of Medical AI Research and Development, National Cancer Center Research Institute
Ken Asada: Division of Medical AI Research and Development, National Cancer Center Research Institute
Ryuichiro Nakato: Institute for Quantitative Biosciences, The University of Tokyo
Kanto Shozu: Division of Medical AI Research and Development, National Cancer Center Research Institute
Ai Dozen: Division of Medical AI Research and Development, National Cancer Center Research Institute
Kenbun Sone: Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo
Hiroshi Yoshida: Division of Diagnostic Pathology, National Cancer Center Hospital
Tomoyasu Kato: Department of Gynecology, National Cancer Center Hospital
Katsutoshi Oda: Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo
Yutaka Osuga: Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo
Tomoyuki Fujii: Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo
Gottfried von Keudell: Memorial Sloan-Kettering Cancer Center
Vassiliki Saloura: Center for Cancer Research, National Cancer Institute
Ryuji Hamamoto: Division of Medical AI Research and Development, National Cancer Center Research Institute

DOI: https://doi.org/10.1038/s42003-021-02992-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Machino et al discover that low expression of microtubule affinity-regulating kinase 3 (MARK3) correlates with poor prognosis in high-grade serous ovarian carcinoma (HGSOC) patients. They find that the LKB1-MARK3 axis is activated by metabolic stress to block the cell cycle at the G2/M checkpoint, and characterise other MARK3 regulated pathways through RNA and ATAC sequencing.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal