Nature Communications (Apr 2017)

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

  • Amy T. Y. Yeung,
  • Christine Hale,
  • Amy H. Lee,
  • Erin E. Gill,
  • Wendy Bushell,
  • David Parry-Smith,
  • David Goulding,
  • Derek Pickard,
  • Theodoros Roumeliotis,
  • Jyoti Choudhary,
  • Nick Thomson,
  • William C. Skarnes,
  • Gordon Dougan,
  • Robert E. W. Hancock

DOI
https://doi.org/10.1038/ncomms15013
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.