POSTMENOPAUSAL METABOLIC SYNDROME: CORRECTION OF AUTONOMIC NERVOUS SYSTEM DISBALANCE WITH COMBINATION OF ACE-INHIBITOR AND STATIN

Abstract

Aim. To study dynamics of the indices of heart rate variability (HRV) and heart remodeling in response on combined therapy with fosinopril and simvastatin in postmenopausal metabolic syndrome (MS). Material and methods. 95 women were dynamically examined (before and after 12 months of therapy with fosinopril and simvastatin) to assess heart rhythm variability (time and spectral domains) and remodeling with Holter ECG monitoring and echocardiography. Results. Fosinopril has resulted in blood pressure decrease, reduction in heart remodeling andmyocardial heterogeneity , which accompanied HRV rise with increase in parasympathetic activity. Simvastatin potentiated fosinopril positive effects on left ventricular hypertrophy , myocardial electric heterogeneity and autonomic modulation due to its prominent hypolipidemic and pleiotropic effect. Conclusion. In patients with postmenopausal MS medicines, which modified different elements of MS (ACE inhibitor and statin), not only have antihypertensive and hypolipidemic action, but also reduce the heart remodeling and improve the autonomic nervous system balance.

Keywords

• heart rate variability
• fosinopril
• simvastatin
• postmenopausal syndrome
• metabolic syndrome