Correlation between Serum Albumin Level and Severity of Acute Ischemic Stroke : A Cross-Sectional Study

Abstract

Introduction: Stroke is a leading cause of disability with devastating consequences. Serum albumin has emerged as a significant prognostic marker in various conditions, including stroke. This study aims to investigate the relationship between serum albumin levels and stroke severity and outcomes in patients with acute ischemic stroke (AIS). Methods: An observational, cross-sectional study was conducted over six months at Bir Hospital, among patients admitted in medicine ward. Total population sampling was done. Serum albumin at the time of diagnosis was measured. Ischemic stroke severity was scored based on NIHSS score on admission and the functional outcome was evaluated as modified Rankin Scale (mRS). Finally, correlation of serum albumin with the severity and the outcome of stroke (mRS) was made. Results: The study of 37 patients showed significant correlation between serum albumin and NIHS score. For high severity (NIHSS≥10), logistic regression analysis identified (OR: 0.086; 95% CI: 0.01-0.75, p-value 0.027) indicating there is strong association between serum albumin and NIHSS score (or severity). The study showed significant correlation between serum albumin and modified Rankin scale at the 0.01 level (2 tailed). The mean serum albumin level was 0.364 units higher (95% CI: 0.103 to 0.625) units higher in non-poor mRS score compared to poor mRS score. P-value of 0.003 suggested strong association between Serum albumin and mRS score. Conclusion: Significant correlation of serum albumin level with clinical severity at the time of admission and with the outcome during discharge was found. Thus serum albumin has prognostic significance in acute ischemic stroke.

Keywords

• acute ischemic stroke
• albumin
• national institute of health stroke scale
• modified rankin scale