Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y45 That Inhibit Nitric Oxide Production

Xiaoya Qin; Jiguo Huang; Dexiong Zhou; Wenxiu Zhang; Yanjun Zhang; Jun Li; Ruiyun Yang; Xishan Huang

doi:10.3390/md20010005

Marine Drugs (Dec 2021)

Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y45 That Inhibit Nitric Oxide Production

Xiaoya Qin,
Jiguo Huang,
Dexiong Zhou,
Wenxiu Zhang,
Yanjun Zhang,
Jun Li,
Ruiyun Yang,
Xishan Huang

Affiliations

Xiaoya Qin: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Jiguo Huang: School of Chemical Engineering and Technology, Guangdong Industry Polytechnic, Guangzhou 510300, China
Dexiong Zhou: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Wenxiu Zhang: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Yanjun Zhang: Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, Beibu Gulf University, Qinzhou 535011, China
Jun Li: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Ruiyun Yang: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China
Xishan Huang: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541005, China

DOI: https://doi.org/10.3390/md20010005
Journal volume & issue: Vol. 20, no. 1
p. 5

Abstract

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Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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