Nature Communications (May 2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue
- Anastasia Georgiadi,
- Valeria Lopez-Salazar,
- Rabih El- Merahbi,
- Rhoda Anane Karikari,
- Xiaochuan Ma,
- André Mourão,
- Katarina Klepac,
- Lea Bühler,
- Ana Jimena Alfaro,
- Isabell Kaczmarek,
- Adam Linford,
- Madeleen Bosma,
- Olga Shilkova,
- Olli Ritvos,
- Nobuhiro Nakamura,
- Shigehisa Hirose,
- Maximilian Lassi,
- Raffaele Teperino,
- Juliano Machado,
- Marcel Scheideler,
- Arne Dietrich,
- Arie Geerlof,
- Annette Feuchtinger,
- Andreas Blutke,
- Katrin Fischer,
- Timo Dirk Müller,
- Katharina Kessler,
- Torsten Schöneberg,
- Doreen Thor,
- Silke Hornemann,
- Michael Kruse,
- Peter Nawroth,
- Olga Pivovarova-Ramich,
- Andreas Friedrich Hermann Pfeiffer,
- Michael Sattler,
- Matthias Blüher,
- Stephan Herzig
Affiliations
- Anastasia Georgiadi
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Valeria Lopez-Salazar
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Rabih El- Merahbi
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Rhoda Anane Karikari
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Xiaochuan Ma
- Department for Cell and Molecular Biology, Karolinska Institute
- André Mourão
- Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health
- Katarina Klepac
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Lea Bühler
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Ana Jimena Alfaro
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Isabell Kaczmarek
- Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig
- Adam Linford
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Madeleen Bosma
- Department for Cell and Molecular Biology, Karolinska Institute
- Olga Shilkova
- Department for Cell and Molecular Biology, Karolinska Institute
- Olli Ritvos
- Biomedicum Helsinki and Department of Bacteriology, Haartman Institute, University of Helsinki
- Nobuhiro Nakamura
- Department of Life Science and Technology, Tokyo Institute of Technology
- Shigehisa Hirose
- Department of Life Science and Technology, Tokyo Institute of Technology
- Maximilian Lassi
- German Center for Diabetes Research (DZD)
- Raffaele Teperino
- German Center for Diabetes Research (DZD)
- Juliano Machado
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Marcel Scheideler
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Arne Dietrich
- Department of Surgery, University of Leipzig
- Arie Geerlof
- Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health
- Annette Feuchtinger
- Core Facility Pathology & Tissue Analytics Research Unit Analytical Pathology, Helmholtz Centre Munich, German Research Center for Environmental Health
- Andreas Blutke
- Core Facility Pathology & Tissue Analytics Research Unit Analytical Pathology, Helmholtz Centre Munich, German Research Center for Environmental Health
- Katrin Fischer
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Timo Dirk Müller
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Katharina Kessler
- German Center for Diabetes Research (DZD)
- Torsten Schöneberg
- Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig
- Doreen Thor
- Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig
- Silke Hornemann
- German Center for Diabetes Research (DZD)
- Michael Kruse
- Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke
- Peter Nawroth
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- Olga Pivovarova-Ramich
- German Center for Diabetes Research (DZD)
- Andreas Friedrich Hermann Pfeiffer
- German Center for Diabetes Research (DZD)
- Michael Sattler
- Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health
- Matthias Blüher
- Department of Medicine, University of Leipzig
- Stephan Herzig
- Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health
- DOI
- https://doi.org/10.1038/s41467-021-22579-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
The soluble bioactive form of the transmembrane protein fibronectin type III domain containing 4 (sFNDC4) has anti-inflammatory effects and improves insulin sensitivity. Here the authors show that liver derived sFNDC4 signals through adipose tissue GPCR GPR116 to promote insulin-mediated glucose uptake.
