The role of some indicators of the antioxidant system and adipose tissue metabolism in predicting isthmic-cervical insufficiency

Abstract

Objective: to evaluate the role of some indicators of antioxidant system and adipose tissue metabolism in predicting preterm birth in pregnant women with isthmic-cervical insufficiency.Materials and methods: the study included 117 pregnant women divided in two clinical groups: group I — 57 pregnant women with isthmic-cervical insufficiency, who underwent surgical cerclage, group II — 60 women with a physiological pregnancy. Using enzyme immunoassay, we determined the levels of superoxide dismutase, catalase, ceruloplasmin, leptin, homocysteine, ghrelin, resistin and adiponectin in the blood serum of pregnant women of clinical groups.Results: it has been established that catalase has the greatest prognostic significance in relation to isthmic-cervical insufficiency on the part of the antioxidant system, and leptin, resistin and homocysteine on the part of adipose tissue metabolism indicators.Conclusions: determination of the level of some isthmic-cervical insufficiency associated indicators of oxidative stress and lipid metabolism in the first trimester of pregnancy can be successfully used to form a risk group, early prediction and timely prevention of isthmic-cervical insufficiency.

Keywords

• isthmic-cervical insufficiency
• uncomplicated pregnancy
• indicators of antioxidant protection
• indicators of adipose tissue metabolism