Nature Communications (Mar 2022)
The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma
- Cunjie Chang,
- Muthukumar Rajasekaran,
- Yiting Qiao,
- Heng Dong,
- Yu Wang,
- Hongping Xia,
- Amudha Deivasigamani,
- Minjie Wu,
- Karthik Sekar,
- Hengjun Gao,
- Mengqing Sun,
- Yuqin Niu,
- Qian Li,
- Lin Tao,
- Zhen Yan,
- Menglan Wang,
- Shasha Chen,
- Shujuan Zhao,
- Dajing Chen,
- Lina Li,
- Fan Yang,
- Haojin Gao,
- Baodong Chen,
- Ling Su,
- Liang Xu,
- Ye Chen,
- Veerabrahma Pratap Seshachalam,
- Gongxing Chen,
- Jayantha Gunaratne,
- Wanjin Hong,
- Junping Shi,
- Gongying Chen,
- David S. Grierson,
- Benoit Chabot,
- Tian Xie,
- Kam Man Hui,
- Jianxiang Chen
Affiliations
- Cunjie Chang
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Muthukumar Rajasekaran
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Yiting Qiao
- The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, School of Medicine, Zhejiang University
- Heng Dong
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Yu Wang
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Hongping Xia
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Amudha Deivasigamani
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Minjie Wu
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Karthik Sekar
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Hengjun Gao
- Department of Hepatopancreatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University
- Mengqing Sun
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Yuqin Niu
- The First Affiliated Hospital, School of Medicine, Shihezi University
- Qian Li
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Lin Tao
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Zhen Yan
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Menglan Wang
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Shasha Chen
- Department of Traditional Chinese Medicine, Taizhou Cancer Hospital
- Shujuan Zhao
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Dajing Chen
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Lina Li
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Fan Yang
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Haojin Gao
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Baodong Chen
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Ling Su
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Liang Xu
- Cancer Science Institute of Singapore, National University of Singapore
- Ye Chen
- Cancer Science Institute of Singapore, National University of Singapore
- Veerabrahma Pratap Seshachalam
- Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre
- Gongxing Chen
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Jayantha Gunaratne
- Institute of Molecular and Cell Biology, A*STAR, Biopolis Drive Proteos
- Wanjin Hong
- Institute of Molecular and Cell Biology, A*STAR, Biopolis Drive Proteos
- Junping Shi
- Institute of Hepatology and Metabolic Diseases, Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University
- Gongying Chen
- Institute of Hepatology and Metabolic Diseases, Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University
- David S. Grierson
- Faculty of Pharmaceutical Sciences, University of British Columbia
- Benoit Chabot
- Département de Microbiologie et d’Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke
- Tian Xie
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Kam Man Hui
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- Jianxiang Chen
- School of Pharmacy and Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University
- DOI
- https://doi.org/10.1038/s41467-022-29016-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Alternative splicing is dysregulated in hepatocellular carcinoma. Here, the authors investigate the role of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich splicing factor 10 (SRSF10) in sustaining the oncogenic signal.
