Diapause is associated with a change in the polarity of secretion of insulin-like peptides

Abstract

Insulin-like peptides INS-7 and INS-35 suppress larval diapause in Caenorhabditis elegans via unknown mechanism. Here, Matsunaga et al.show that the secretory polarity of both peptides changes in diapause, when these peptides are secreted into the intestinal lumen instead of the body cavity like in other larval stages.