METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Yuqin Wang; Ming Gao; Fuxing Zhu; Xinzhi Li; Ying Yang; Qiuxin Yan; Linna Jia; Liwei Xie; Zheng Chen

doi:10.1038/s41467-020-15488-2

Nature Communications (Apr 2020)

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Yuqin Wang,
Ming Gao,
Fuxing Zhu,
Xinzhi Li,
Ying Yang,
Qiuxin Yan,
Linna Jia,
Liwei Xie,
Zheng Chen

Affiliations

Yuqin Wang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Ming Gao: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Fuxing Zhu: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Xinzhi Li: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Ying Yang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Qiuxin Yan: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Linna Jia: Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), School of Life Sciences, Northeast Normal University
Liwei Xie: State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences
Zheng Chen: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s41467-020-15488-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in eukaryotes. Here the authors show that the m6A writer protein methyltransferase-like (METTL) 3 plays an important role for the development of brown adipose tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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