Nature Communications (Mar 2019)
Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway
- Song Ho Chang,
- Daisuke Mori,
- Hiroshi Kobayashi,
- Yoshifumi Mori,
- Hideki Nakamoto,
- Keita Okada,
- Yuki Taniguchi,
- Shurei Sugita,
- Fumiko Yano,
- Ung-il Chung,
- Joo-ri Kim-Kaneyama,
- Motoko Yanagita,
- Aris Economides,
- Ernesto Canalis,
- Di Chen,
- Sakae Tanaka,
- Taku Saito
Affiliations
- Song Ho Chang
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Daisuke Mori
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroshi Kobayashi
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Yoshifumi Mori
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Hideki Nakamoto
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Keita Okada
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Yuki Taniguchi
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Shurei Sugita
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Fumiko Yano
- Bone and Cartilage Regenerative Medicine, Graduate School of Medicine, The University of Tokyo
- Ung-il Chung
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Joo-ri Kim-Kaneyama
- Department of Biochemistry, Showa University School of Medicine
- Motoko Yanagita
- Department of Nephrology, Graduate School of Medicine, Kyoto University
- Aris Economides
- Regeneron Pharmaceuticals, Inc.
- Ernesto Canalis
- Departments of Orthopaedic Surgery and Medicine and the Musculoskeletal Institute, UConn Heath
- Di Chen
- Department of Orthopedic Surgery, Rush University Medical Center
- Sakae Tanaka
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- Taku Saito
- Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-019-09491-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.
