Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I

Etienne Galemou Yoga; Kristian Parey; Amina Djurabekova; Outi Haapanen; Karin Siegmund; Klaus Zwicker; Vivek Sharma; Volker Zickermann; Heike Angerer

doi:10.1038/s41467-020-19778-7

Nature Communications (Nov 2020)

Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I

Etienne Galemou Yoga,
Kristian Parey,
Amina Djurabekova,
Outi Haapanen,
Karin Siegmund,
Klaus Zwicker,
Vivek Sharma,
Volker Zickermann,
Heike Angerer

Affiliations

Etienne Galemou Yoga: Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Goethe University
Kristian Parey: Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Goethe University
Amina Djurabekova: Department of Physics, P.O. Box 64, University of Helsinki
Outi Haapanen: Department of Physics, P.O. Box 64, University of Helsinki
Karin Siegmund: Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Goethe University
Klaus Zwicker: Medical School, Institute of Biochemistry I, Goethe University
Vivek Sharma: Department of Physics, P.O. Box 64, University of Helsinki
Volker Zickermann: Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Goethe University
Heike Angerer: Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Goethe University

DOI: https://doi.org/10.1038/s41467-020-19778-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex. These findings offer insight into the mechanism of proton pumping by respiratory complex I.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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