Nature Communications (May 2019)
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
- Ylenia Perone,
- Aaron J. Farrugia,
- Alba Rodríguez-Meira,
- Balázs Győrffy,
- Charlotte Ion,
- Andrea Uggetti,
- Antonios Chronopoulos,
- Pasquale Marrazzo,
- Monica Faronato,
- Sami Shousha,
- Claire Davies,
- Jennifer H. Steel,
- Naina Patel,
- Armando del Rio Hernandez,
- Charles Coombes,
- Giancarlo Pruneri,
- Adrian Lim,
- Fernando Calvo,
- Luca Magnani
Affiliations
- Ylenia Perone
- Department of Surgery and Cancer, Imperial College London
- Aaron J. Farrugia
- Division of Cancer Biology, Tumour Microenvironment Team, Institute of Cancer Research
- Alba Rodríguez-Meira
- Department of Surgery and Cancer, Imperial College London
- Balázs Győrffy
- MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences
- Charlotte Ion
- Department of Surgery and Cancer, Imperial College London
- Andrea Uggetti
- European Institute of Oncology
- Antonios Chronopoulos
- Faculty of Engineering, Department of Bioengineering, Imperial College London
- Pasquale Marrazzo
- Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna
- Monica Faronato
- Department of Chemistry, Imperial College London
- Sami Shousha
- Histopathology Department, Imperial College London, Charing Cross Hospital NHS Trust
- Claire Davies
- ECMC Imperial College. Department of Surgery and Cancer, Imperial College London
- Jennifer H. Steel
- ECMC Imperial College. Department of Surgery and Cancer, Imperial College London
- Naina Patel
- ECMC Imperial College. Department of Surgery and Cancer, Imperial College London
- Armando del Rio Hernandez
- Faculty of Engineering, Department of Bioengineering, Imperial College London
- Charles Coombes
- Department of Surgery and Cancer, Imperial College London
- Giancarlo Pruneri
- Pathology Department, Fondazione IRCCS Istituto Nazionale Tumori and University of Milan, School of Medicine
- Adrian Lim
- Department of Surgery and Cancer, Imperial College London
- Fernando Calvo
- Division of Cancer Biology, Tumour Microenvironment Team, Institute of Cancer Research
- Luca Magnani
- Department of Surgery and Cancer, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-019-09676-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion.
