Türk Oftalmoloji Dergisi (Oct 2018)

Real-World Outcomes of Anti-VEGF Treatment for Neovascular Age-Related Macular Degeneration in Turkey: A Multicenter Retrospective Study, Bosphorus Retina Study Group Report No: 1

  • Abdullah Özkaya,
  • Levent Karabaş,
  • Cengiz Alagöz,
  • Zeynep Alkın,
  • Özgür Artunay,
  • Selim Bölükbaşı,
  • Gökhan Demir,
  • Mehmet Demir,
  • Ali Demircan,
  • Burak Erden,
  • Gürkan Erdoğan,
  • Mehmet Erdoğan,
  • Erdem Eriş,
  • Havva Kaldırım,
  • İsmail Umut Onur,
  • Özen Osmanbaşoğlu,
  • Sezin Özdoğan Erkul,
  • Mine Öztürk,
  • İrfan Perente,
  • Kübra Sarıcı,
  • Nihat Sayın,
  • Dilek Yaşa,
  • İhsan Yılmaz,
  • Zeynep Yılmazabdurrahmanoğlu

DOI
https://doi.org/10.4274/tjo.31697
Journal volume & issue
Vol. 48, no. 5
pp. 232 – 237

Abstract

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Objectives: To evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (nAMD) patients. Materials and Methods: Multicenter, retrospective, interventional, non-comparative study. The records of nAMD patients treated with an anti-VEGF agent on a pro re nata treatment regimen basis between January 2013 and December 2015 were reviewed. The patients who completed a follow-up period of 12 months were included. Primary outcome measures of this study were the visit and injection numbers during the first year. Results: Eight hundred eighty eyes of 783 patients met the inclusion criteria for the study. Mean number of visits at month 12 was 6.9±2.5 (range: 1-15). Mean number of injections at month 12 was 4.1±1.9 (range: 1-11). Mean visual acuity at baseline and months 3, 6, and 12 was 0.90±0.63 LogMAR (range: 0.0-3.0), 0.79±0.57 LogMAR (range: 0.0-3.0), 0.76±0.57 LogMAR (range: 0.0-3.0), and 0.79±0.59 LogMAR (range: 0.0-3.0), respectively. Mean central retinal thickness at baseline and months 6 and 12 was 395±153 μm (range: 91-1582), 330±115 μm (range: 99-975), and 332±114 μm (range: 106-1191), respectively. Conclusion: The numbers of visits and injections were much lower than ideal and were insufficient with the pro re nata treatment regimen.

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