On inotropic effects of UTP in the human heart

J. Neumann; B. Hofmann; U. Gergs

Heliyon (Aug 2019)

On inotropic effects of UTP in the human heart

J. Neumann,
B. Hofmann,
U. Gergs

Affiliations

J. Neumann: Institute for Pharmacology and Toxicology, Germany; Corresponding author.
B. Hofmann: Cardiac Surgery, Medical Faculty, Martin-Luther University Halle-Wittenberg, 06097, Halle (Saale), Germany
U. Gergs: Institute for Pharmacology and Toxicology, Germany

Journal volume & issue: Vol. 5, no. 8
p. e02197

Abstract

Read online

Uridine 5′-triphosphate (UTP) exerts a positive inotropic effect (PIE) in isolated electrically driven isolated right atrial trabeculae carneae from patients undergoing heart surgery. This review discusses some aspects of the current knowledge on the putative receptor(s) involved and the potential biochemical transduction steps leading to the PIE.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

About the journal

Abstract

Keywords