STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

Anna Woroniuk; Andrew Porter; Gavin White; Daniel T. Newman; Zoi Diamantopoulou; Thomas Waring; Claire Rooney; Douglas Strathdee; Daniel J. Marston; Klaus M. Hahn; Owen J. Sansom; Tobias Zech; Angeliki Malliri

doi:10.1038/s41467-018-04404-4

Nature Communications (May 2018)

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

Anna Woroniuk,
Andrew Porter,
Gavin White,
Daniel T. Newman,
Zoi Diamantopoulou,
Thomas Waring,
Claire Rooney,
Douglas Strathdee,
Daniel J. Marston,
Klaus M. Hahn,
Owen J. Sansom,
Tobias Zech,
Angeliki Malliri

Affiliations

Anna Woroniuk: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Andrew Porter: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Gavin White: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Daniel T. Newman: Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool
Zoi Diamantopoulou: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Thomas Waring: Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool
Claire Rooney: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester
Douglas Strathdee: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road
Daniel J. Marston: Department of Pharmacology, University of North Carolina
Klaus M. Hahn: Department of Pharmacology, University of North Carolina
Owen J. Sansom: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road
Tobias Zech: Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool
Angeliki Malliri: Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester

DOI: https://doi.org/10.1038/s41467-018-04404-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The perinuclear actin cap determines nuclear morphology but its regulation is currently poorly understood. Here, the authors find that an activator of the Rac1 GTPase, STEF/TIAM2, localises to the nuclear envelope and contributes to perinuclear actin and myosin tension, which in turn regulates the actin cap.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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