Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of <i>Crotalaria cleomifolia</i> Used in Popular Beverages in Madagascar

Anjaramampionona Henintsoa Duvale Solofomalala; Clara Fredeline Rajemiarimoelisoa; Randriamampianina Lovarintsoa Judicael; Hanitra Ranjana Randrianarivo; Danielle Aurore Doll Rakoto; Victor Louis Jeannoda; Ahcène Boumendjel

doi:10.3390/molecules26113464

Molecules (Jun 2021)

Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of <i>Crotalaria cleomifolia</i> Used in Popular Beverages in Madagascar

Anjaramampionona Henintsoa Duvale Solofomalala,
Clara Fredeline Rajemiarimoelisoa,
Randriamampianina Lovarintsoa Judicael,
Hanitra Ranjana Randrianarivo,
Danielle Aurore Doll Rakoto,
Victor Louis Jeannoda,
Ahcène Boumendjel

Affiliations

Anjaramampionona Henintsoa Duvale Solofomalala: Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar
Clara Fredeline Rajemiarimoelisoa: Pharmacy Department, Faculty of Medicine, University of Antananarivo, P.O. Box 375, Antananarivo 101, Madagascar
Randriamampianina Lovarintsoa Judicael: Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar
Hanitra Ranjana Randrianarivo: Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar
Danielle Aurore Doll Rakoto: Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar
Victor Louis Jeannoda: Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar
Ahcène Boumendjel: Univ. Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France

DOI: https://doi.org/10.3390/molecules26113464
Journal volume & issue: Vol. 26, no. 11
p. 3464

Abstract

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Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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