Enantioselective decarboxylative chlorination of β-ketocarboxylic acids

Kazutaka Shibatomi; Kazumasa Kitahara; Nozomi Sasaki; Yohei Kawasaki; Ikuhide Fujisawa; Seiji Iwasa

doi:10.1038/ncomms15600

Nature Communications (Jun 2017)

Enantioselective decarboxylative chlorination of β-ketocarboxylic acids

Kazutaka Shibatomi,
Kazumasa Kitahara,
Nozomi Sasaki,
Yohei Kawasaki,
Ikuhide Fujisawa,
Seiji Iwasa

Affiliations

Kazutaka Shibatomi: Department of Environmental and Life Sciences, Toyohashi University of Technology
Kazumasa Kitahara: Department of Environmental and Life Sciences, Toyohashi University of Technology
Nozomi Sasaki: Department of Environmental and Life Sciences, Toyohashi University of Technology
Yohei Kawasaki: Department of Environmental and Life Sciences, Toyohashi University of Technology
Ikuhide Fujisawa: Department of Environmental and Life Sciences, Toyohashi University of Technology
Seiji Iwasa: Department of Environmental and Life Sciences, Toyohashi University of Technology

DOI: https://doi.org/10.1038/ncomms15600
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 7

Abstract

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Due to the synthetic utility of the products, stereoselective halogenation is a powerful method for the synthesis of chiral compounds. Here the authors report an enantioselective decarboxylative chlorination, giving access to a range of α-chloroketones.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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