A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

Abstract

Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p p p Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.

Keywords

• probiotics
• <i>Lactobacillus casei</i> LTL1879
• healthy young people
• blood biochemical
• oxidant
• inflammation