Nature Communications (Nov 2016)
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Abstract
Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss the implications for receptor trafficking.