Oxidative Stress in Patients with Diabetes Mellitus Type 2 Associated with Exacerbation of Chronic Pyelonephritis

Abstract

The article presents information on the state of the oxidation-reduction process in exacerbation of chronic pyelonephritis (CP) in patients with diabetes mellitus (DM) type 2. The objective of the study — evaluation of the degree of oxidative stress (OS) and the state of the antioxidant system in patients with exacerbation of chronic pyelonephritis due to DM type 2. Materials and Methods. Under clinical supervision there were 88 patients with CP against DM type 2 background aged from 43 to 80 years. The first group of patients received therapy with lomefloxacin or ceftriaxone, as well as hypoglycemic agents. Another group received antibiotic and glucose-lowering therapy, as combination of canephron H and thiotriazoline. The Results of the Study. In patients with comorbid disorders, CH exacerbation are associated with more significant pro-oxidant processes. Adding to antibiotic and glucose-lowering therapy the combination of canephron H and thiotriazoline increases the efficiency of the treatment process and has a positive effect on the state of oxidation-reduction potential of the body. Conclusions. In blood serum of patients with CP against DM 2 we noted been a sharp increase in the processes of oxidative modification of proteins (MBP). Treatment of patients has a positive effect on the process of biomolecules oxidation, particularly for the induced process, that indicates increased resistance of proteins to peroxidation.

Keywords

• diabetes mellitus
• chronic pyelonephritis
• oxidativе stress