Pteridines (Feb 2011)

Correlation of Peripheral Blood CD14+CD16+ Monocytes, Urinary Neopterin and the Risk Factors of Atherosclerosis in Patients with Breast Carcinoma

  • Králíčková Pavlína,
  • Kalábová Hana,
  • Krčmová Lenka,
  • Kašparová Markéta,
  • Plíšek Jiří,
  • Ungermann Leoš,
  • Vokurková Doris,
  • Hyšpler Radomír,
  • Pecka Miroslav,
  • Šrámek Vlastislav,
  • Študentová Hana,
  • Zezulová Michaela,
  • Solichová Dagmar,
  • Melichar Bohuslav

DOI
https://doi.org/10.1515/pteridines.2011.22.1.66
Journal volume & issue
Vol. 22, no. 1
pp. 66 – 72

Abstract

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Monocytes/macrophages are thought to play a fundamental role in the development of vascular lesions in atherosclerosis. In the present study, we evaluated circulating CD14+CD16+ monocytes, laboratory parameters of the risk of atherosclerosis, including serum cholesterol, homocysteine and C-reactive protein, urinary neopterin, serum a-tocopherol and retinol along with carotid intima-media thickness in patients with breast carcinoma. A significant correlation was observed between the absolute numbers of CD14+CD16+ monocytes, serum HDL cholesterol and triglyceride concentrations. In conclusion, present data extend the observation of an association between peripheral blood CD14+CD16+ monocyte counts and lipid metabolism to cancer patients. No correlation of CD14+CD16+ monocyte counts with urinary neopterin concentrations was observed.

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