An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

Abstract

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.

Keywords

• anti-HBV
• enantiopure
• (R)-heteroarylpyrimidines
• chiral separation
• diastereomer