A somatic proteoglycan controls Notch-directed germ cell fate

Sandeep Gopal; Aqilah Amran; Andre Elton; Leelee Ng; Roger Pocock

doi:10.1038/s41467-021-27039-4

Nature Communications (Nov 2021)

A somatic proteoglycan controls Notch-directed germ cell fate

Sandeep Gopal,
Aqilah Amran,
Andre Elton,
Leelee Ng,
Roger Pocock

Affiliations

Sandeep Gopal: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
Aqilah Amran: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
Andre Elton: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
Leelee Ng: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University
Roger Pocock: Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/s41467-021-27039-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Notch receptor GLP-1 is required for maintaining germ cells in the C. elegans germline. Here the authors show that syndecan-1, a somatic transmembrane proteoglycan regulates expression of glp-1 and germ cell mitosis in C. elegans, by promoting calcium-dependent binding of APTF-2 to the glp-1 promoter.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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