Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion

Affiliations

Jessica Migliavacca: Pediatric Molecular Neuro-Oncology Research, Division of Oncology, Children’s Research Center, University Children’s Hospital Zürich
Buket Züllig: Pediatric Molecular Neuro-Oncology Research, Division of Oncology, Children’s Research Center, University Children’s Hospital Zürich
Charles Capdeville: Pediatric Molecular Neuro-Oncology Research, Division of Oncology, Children’s Research Center, University Children’s Hospital Zürich
Michael A. Grotzer: Division of Oncology, University Children’s Hospital Zürich
Martin Baumgartner: Pediatric Molecular Neuro-Oncology Research, Division of Oncology, Children’s Research Center, University Children’s Hospital Zürich

Abstract

Analysis of the MAP4K4-STRN3 cooperation in medulloblastoma reveals its opposing regulation of Hippo activation and tissue invasion in cancer.