C19-Norditerpenoid Alkaloids from Aconitum szechenyianum

Bei Song; Bingliang Jin; Yuze Li; Fei Wang; Yifu Yang; Yuwen Cui; Xiaomei Song; Zhenggang Yue; Jianli Liu

doi:10.3390/molecules23051108

Molecules (May 2018)

C19-Norditerpenoid Alkaloids from Aconitum szechenyianum

Bei Song,
Bingliang Jin,
Yuze Li,
Fei Wang,
Yifu Yang,
Yuwen Cui,
Xiaomei Song,
Zhenggang Yue,
Jianli Liu

Affiliations

Bei Song: The College of Life Sciences, Northwest University, Xi’an 710069, China
Bingliang Jin: Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yuze Li: The College of Life Sciences, Northwest University, Xi’an 710069, China
Fei Wang: Shaanxi Institute for Food and Drug Control, Xi’an 710065, China
Yifu Yang: Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yuwen Cui: Department of Pharmacy, Xi’an Medical University, Xi’an 710021, China
Xiaomei Song: Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
Zhenggang Yue: Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China
Jianli Liu: The College of Life Sciences, Northwest University, Xi’an 710069, China

DOI: https://doi.org/10.3390/molecules23051108
Journal volume & issue: Vol. 23, no. 5
p. 1108

Abstract

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Three new C19-norditerpenoid alkaloids (1–3), along with two known C19-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppressive effects of compounds 1–5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC50/IC50 values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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